The Course of Urolithiasis over Fifteen Years in Calcium Oxalate Stone Formers under Special, General or No Metaphylaxis
The course of urolithiasis was retrospectively analysed in 66 recurrent calcium oxalate stone formers with a mean rate of stone formation of 16.5±14 stones over a period of 15 years. Due to the fact that all patients were recurrent stone formers, general metaphylaxis was supplemented from the outset by special metaphylaxis, which depended on the respective metabolic dysfunction, ie, thiazide in cases of hypercalciuria and allopurinol in hyperuricosuria. Special metaphylaxis lasted over a mean period of 5.5±2.1 years. Subsequently, 32 patients received general metaphylaxis alone and were followed up at regular intervals over a mean of 5.7±2.6 years. Of this group, 22 were classified as metabolically active stone formers. Thirty four patients were lost to follow-up due to noncompliance; however, 20 could be re-examined after a mean of 6.3±2.2 years. During this time, they had not observed metaphylaxis.