Increased Hepatic Oxalate Production in Rats Treated With Clofibrate
Peroxisomes are thought to play an important role in hepatic metabolism1, 2. In oxalate stone disease where urinary oxalate is derived mainly from endogenous metabolic processes3, peroxisomes are important in that they are a site of oxalate production4 with glycollate oxidase, amino acid oxidase, glyoxylate:alanine aminotransferases and catalase being present in these organelles2, 5–7. The hypolipidaemic drug, clofibrate, causes both peroxisomal proliferation and alterations in the activity of enzymes located in these organelles, particularly catalase1, 8, 9. Clofibrate therefore offers a means of better understanding the regulation of hepatic oxalate production. In this study we describe the effect of clofibrate administration on the changes in enzyme activities and the corresponding effects on oxalate production in hepatocytes isolated from clofibrate-treated rats.
KeywordsUrinary Oxalate Glycollate Oxidase Hepatocyte Suspension Amino Acid Oxidase Hypolipidaemic Drug
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