Abstract
Iron balance is regulated primarily by keeping the absorptive process attuned to body requirements. While iron loss from the body is quantitatively as important as iron absorption, excretion is limited and plays a more passive role [1]. It has been known for many years that iron is absorbed in the small intestine. However, the mechanisms involved in mucosal uptake of dietary iron and mucosal transfer of iron into the plasma are poorly understood. In non-intestinal cells which possess transferrin receptors on their surface, iron is believed to enter the cell via a transferrin, transferrin-receptor clathrin mediated mechanism [2]. However, recent publications suggest that there may be an alternative pathway [3-5].
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Conrad, M.E., Umbreit, J.N., Moore, E.G. (1994). Iron Absorption and Cellular Uptake of Iron. In: Hershko, C., Konijn, A.M., Aisen, P. (eds) Progress in Iron Research. Advances in Experimental Medicine and Biology, vol 356. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2554-7_8
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