Abstract
The high concentration of lactoferrin in human milk throughout lactation suggests that this protein fulfils some biological role in the development of the newborn infant. Various functions have been proposed, including regulation of iron absorption and development of the gut flora, stimulation of the immune system, and maturation of the gastrointestinal tract (reviewed by Sanchez et al, 1992a).
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References
Anderson BF, Baker HM, Norris GE, Rumball SV, Baker EN (1990) Apolactoferrin structure demonstrates ligand-induced conformational change in transférons. Nature (London) 344: 784–787.
Donovan JW (1977) Differences between ovotransferrin and human serum transferrin in structural and metalbinding cooperativity. In Proteins of iron metabolism (Ed Brown EB, Aisen P, Fielding J, Crichton RR), Grune and Stratton, New York, pp 179–186.
Iturralde M., Vass JK, Oria R, Brock JH (1992) Effect of iron and retinoic acid on the control of transferrin receptor and ferritin in the human promonocytic cell line U937. Biochim Biophys Acta 1133: 241–246.
Lampreave F, Piñeiro A, Brock JH, Castillo H, Sánchez L, Calvo M (1990) Interaction of bovine lactoferrin with other proteins of milk whey. Int J Biol Macromol. 12: 2–5.
Oria R, Alvarez-Hernandez X, Licéaga J, Brock JH (1988) Uptake and handling of iron from transferrin, lactoferrin and immune complexes by a macrophage cell line. Biochem J 252: 221–225
Sánchez L, Calvo M., Brock JH (1992a) Biological role of lactoferrin. Arch Dis Child 67: 657–661.
Sánchez L, Peiró JM, Castillo H, Pérez MD, Ena JM, Calvo M (1992b) Kinetic parameters for denaturation of bovine milk lactoferrin. J Food Sci 57: 873–879.
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© 1994 Springer Science+Business Media New York
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Sánchez, L., Peiró, J.M., Oria, R., Castillo, H., Brock, J.H., Calvo, M. (1994). Kinetic Parameters for the Heat Denaturation of Bovine Lactoferrin in Milk, and its Effect on Interaction with Monocytes. In: Hutchens, T.W., Rumball, S.V., Lönnerdal, B. (eds) Lactoferrin. Advances in, Experimental Medicine and Biology, vol 357. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2548-6_27
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DOI: https://doi.org/10.1007/978-1-4615-2548-6_27
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