Abstract
Lactoferrin (Lf)** is abundant in human milk. The physiological role of milk Lf is still debated but it is believed to exhibit a bacteriostatic effect in the small intestine. It has also been speculated whether Lf is actively taking part in iron absorption during infancy (1). Cox et al. (2) showed that human lactoferrin (HLf) has the ability to deliver iron to mucosal human intestinal biopsies. Recent evidence for the presence of specific Lf receptors in the small intestine has been provided in rhesus monkeys (3), mice (4) and humans (5) using brush border membranes. It should be noted that all these species have a relatively high Lf concentration in their milk. This may suggest that Lf plays a role in receptor mediated iron absorption in these species.
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© 1994 Springer Science+Business Media New York
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Gíslason, J., Iyer, S., Douglas, G.C., Hutchens, T.W., Lönnerdal, B. (1994). Binding of Porcine Milk Lactoferrin to Piglet Intestinal Lactoferrin Receptor. In: Hutchens, T.W., Rumball, S.V., Lönnerdal, B. (eds) Lactoferrin. Advances in, Experimental Medicine and Biology, vol 357. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2548-6_25
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DOI: https://doi.org/10.1007/978-1-4615-2548-6_25
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