The Role of MRI Volumetric Studies in The Investigation of Patients with Intractable Epilepsy
The assessment of intractable epilepsy has traditionally depended on analysis of clinical seizure patterns in association with a searching EEG investigation. EEG recording of seizures is still considered necessary for seizure localisation prior to surgical treatment in patients without an obvious lesion on MRI. Radiological and neuropsychological studies are also essential for pre-surgical investigation. When the findings are not completely congruous, or when there are seeming contradictions in surface and sphenoidal recordings, monitoring with surgically implanted depth electrodes may be required. However, there is a significant risk of morbidity associated with the implantation of depth electrodes. This, together with the limited availability and high costs of the procedure, reduces the number of patients who can benefit from surgical treatment.
KeywordsTemporal Lobe Epilepsy Hippocampal Volume Hippocampal Sclerosis Intractable Epilepsy Febrile Convulsion
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