Proton MR Spectroscopic Imaging in The Investigation of Patients with Temporal Lobe Epilepsy
MR spectroscopy (MRS) is a non-invasive technique that allows direct identification and quantitation of certain cerebral metabolites in vivo without the injection of radionuclides. Initial studies on small numbers of patients using phosphorus MRS demonstrated a relative alkalosis and an increase in inorganic phosphate in the temporal lobe responsible for temporal lobe epilepsy (TLE) (Kuzniecky et al, 1992; Laxer et al., 1992). Proton MRS has the advantage of much greater signal-to-noise ratio and, therefore, greater spatial resolution compared to phosphorus spectroscopy. Proton MRS studies reported to date have revealed a reduced N-acetylaspartate (NAA) relative resonance intensity in the temporal lobes of patients with TLE (Cendes et al., 1994; Matthews et al., 1990; Laxer et al., 1992).
KeywordsPhosphorus Lactate Radionuclide Neurol Reso
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