Abstract
MR spectroscopy (MRS) is a non-invasive technique that allows direct identification and quantitation of certain cerebral metabolites in vivo without the injection of radionuclides. Initial studies on small numbers of patients using phosphorus MRS demonstrated a relative alkalosis and an increase in inorganic phosphate in the temporal lobe responsible for temporal lobe epilepsy (TLE) (Kuzniecky et al, 1992; Laxer et al., 1992). Proton MRS has the advantage of much greater signal-to-noise ratio and, therefore, greater spatial resolution compared to phosphorus spectroscopy. Proton MRS studies reported to date have revealed a reduced N-acetylaspartate (NAA) relative resonance intensity in the temporal lobes of patients with TLE (Cendes et al., 1994; Matthews et al., 1990; Laxer et al., 1992).
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© 1994 Springer Science+Business Media New York
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Cendes, F., Andermann, F., Arnold, D.L. (1994). Proton MR Spectroscopic Imaging in The Investigation of Patients with Temporal Lobe Epilepsy. In: Shorvon, S.D., Fish, D.R., Andermann, F., Bydder, G.M., Stefan, H. (eds) Magnetic Resonance Scanning and Epilepsy. NATO ASI Series, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2546-2_37
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