Proton MR Spectroscopic Imaging in The Investigation of Patients with Temporal Lobe Epilepsy
MR spectroscopy (MRS) is a non-invasive technique that allows direct identification and quantitation of certain cerebral metabolites in vivo without the injection of radionuclides. Initial studies on small numbers of patients using phosphorus MRS demonstrated a relative alkalosis and an increase in inorganic phosphate in the temporal lobe responsible for temporal lobe epilepsy (TLE) (Kuzniecky et al, 1992; Laxer et al., 1992). Proton MRS has the advantage of much greater signal-to-noise ratio and, therefore, greater spatial resolution compared to phosphorus spectroscopy. Proton MRS studies reported to date have revealed a reduced N-acetylaspartate (NAA) relative resonance intensity in the temporal lobes of patients with TLE (Cendes et al., 1994; Matthews et al., 1990; Laxer et al., 1992).
KeywordsTemporal Lobe Temporal Lobe Epilepsy Proton Magnetic Resonance Spectroscopy Temporal Lobe Epilepsy Patient Resonance Intensity
Unable to display preview. Download preview PDF.
- Arnold, D. L., 1992, Reversible reduction of N-acetylaspartate after acute central nervous system damage, Proc Soc Magn Reson Med. 11: 643 (abstract).Google Scholar
- Babb, T. L., and Brown, W. J., 1987, Pathological findings in epilepsy, in: “Surgical treatment of the epilepsies,” Engel J, Jr, ed., Raven Press, New York.Google Scholar
- Bruton, C. J., 1988, “The Neuropathology of Temporal Lobe Epilepsy,” Oxford University Press, New York.Google Scholar
- Coyle, J. T., Robinson, M. B., Blakely, R. D., and Forloni, G-L., 1989, The neurobiology of N-acetyl-aspartyl-glutamate, in: “Allosteric modulation of amino acid receptors: therapeutic implications,” E. A. Barnard and E. Costa, eds, Raven Press, New York.Google Scholar
- Gloor, P., 1991, Mesial temporal sclerosis: historical background and an overview from a modern perspective, in: “Epilepsy Surgery,” H. Luders, ed., Raven Press, New York.Google Scholar
- Meencke, H. J., and Veith, G., 1991, Hippocampal sclerosis in epilepsy, in: “Epilepsy Surgery,” H. Luders, ed., Raven Press, New York.Google Scholar
- Slopis, J. M., Lin, S., Butler, J. M., and Caprioli, R., 1992, Selective Corelease of N-Acetylaspartylglutamate and N-Acetyl-Aspartate from rat hypothalamus in vivo. Ann Neurol. 32(3): 445–446 (abstract).Google Scholar
- Tallen, H. H., 1957, Studies on the distribution of N-acetyl-L-aspartic acid in brain, J Biol Chem. 224: 41–45.Google Scholar