Abstract
A variety of imaging techniques have been used to characterise the ictal and inter-ictal metabolic abnormalities associated with focal epilepsy. Position emission tomography (PET) and SPECT scanning have demonstrated the inter-ictal focus to be hypoperfused and hypometabolic. Magnetic resonance spectroscopy (MRS) allows the non-invasive measuring of chemicals within the body and can be performed on many conventional MRI systems. MRS exploits the principle that every chemically distinct nucleus in a compound resonates at a slightly different frequency. Nuclear magnetic resonance (NMR) signals from many compounds can be detected simultaneously in one MRS experiment and magnetic resonance spectroscopic imaging (MRSI) with phase encoding has the ability to obtain MRS signals from multiple regions simultaneously. 1H MRS detects N-acetylaspartate (NAA), lactate, choline, creatine/phosphocreatine, and amino acids including glutamate, glutamine, aspartate and taurine. 31P MRS detects phosphocreatine (PCr), ATP, inorganic phosphate (Pi), pH (from the chemical shift of Pi), free Mg2+ (from the chemical shift of ATP), phosphomonoesters (PME), and phosphodiesters (PDE). PCr, ATP, Pi, pH and lactate provide information concerning bioenergetics. PDE, PME and choline provide information regarding lipid metabolism (Matson and Weiner, 1992). MRS studies in animals and in human neonates during seizures have confirmed previously reported alterations in energy metabolism including the depletion of PCr, ATP, and increased Pi, lactate and H+ (Young et al., 1985; Younkin et al., 1986). With the recognised metabolic abnormalities detected by PET and SPECT scanning inter-ictally, we questioned whether or not 1H and 31P MRS could document focal metabolic changes localised to the seizure focus which led to the following pilot studies.
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References
Hugg, J. W., Laxer, K. D., Matson, G. B., Maudsley, A. A., Husted, CA., and Weiner, M. W., 1992, Lateralisation of human focal epilepsy by 31P magnetic resonance spectroscopic imaging, Neurology 42: 2011–2018.
Hugg, J. W., Laxer, K. D., Matson, G. B., Maudsley, A. A., and Weiner, M. W., 1993, Neuron loss localizes human temporal lobe epilepsy by in-vivo proton magnetic resonance, Ann Neurol. 34: 788–794
Laxer, K. D., Hubesch, B., Sappey-Marinier, D. and Weiner, M. W., 1992, Increased pH and inorganic phosphate in temporal seizure foci, demonstrated by 31P MRS, Epilepsia 33: 618–623.
Matson, G. B., and Weiner, M. W., 1992, Spectroscopy, in: “MRI,” D. D. Stark, and W. G. Bradley, eds, C. V. Mosby Yearbook, St. Louis.
Ryvlin, P., Philippon, B., Cinotti, L., Froment, J. C., Le Bars, D., and Mauguiere, F., 1992, Functional neuroimaging strategy in temporal lobe epilepsy: a comparative study of 18FDG-PET and 99mTc-HMPAO-SPECT, Ann Neurol. 31: 650–656.
Young, R. S., Osbakken, M. D., Briggs, R. W., Yagel, S. K., and Rice, D. W., 1985, 31P NMR study of cerebral metabolism during prolonged seizures in the neonatal dog, Ann Neurol. 18: 14–20.
Younkin, D. P., Delivoria-Papadopoulos, M., Maris, J., Donlon, E., Clancy, R., and Chance, B., 1986, Cerebral metabolic effects of neonatal seizures measured with in vivo 31P NMR spectroscopy, Ann Neurol. 20: 513–519.
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© 1994 Springer Science+Business Media New York
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Laxer, K.D., Hugg, J.W., Matson, G.B., Weiner, M.W. (1994). Application of Spectroscopy to Epilepsy. In: Shorvon, S.D., Fish, D.R., Andermann, F., Bydder, G.M., Stefan, H. (eds) Magnetic Resonance Scanning and Epilepsy. NATO ASI Series, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2546-2_36
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DOI: https://doi.org/10.1007/978-1-4615-2546-2_36
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