Abstract
Seizures, mental handicap and axial hypotonia are often the first symptoms of agenesis of the corpus callosum (CA). The clinical pattern varies according to the anatomical findings and aetiology. Indeed, there is a wide spectrum of brain malformations which involve CA. CA is by no means a clinical diagnosis on its own but its recognition is the first step towards a more precise aetiological diagnosis and prognosis. The clinical relevance of this concept grows as prenatal diagnosis of CA becomes more and more accurate. Prenatal diagnosis is presently often made by means of ultrasonography and it is a real challenge in these cases to determine the prognosis.
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References
Aicardi, J., Chevrie, J. J., and Rousselie, F., 1969, Le syndrome spasmes en flexion, agénésie calleuse, anomalies choriorétiniennes, Arch Fr Pediatr 26: 1103–1120.
Andermann, E., Andermann, F., Joubert, M., et al., 1975, Three familial midline malformation syndromes of the central nervous system: agenesis of the corpus callosum and anterior horn-cell disease; agenesis of the cerebellar vermis; and atrophy of the cerebellar vermis, Birth Defects 11: 269–293.
Bour, F., Chiron, C., Dulac, O., et al., 1986, Caractères électro-cliniques des crises dans le syndrome d’Aicardi. Rev, EEG Neurophysiol Clin 16: 341–353.
De Morsier, G., and Mozer, J. J., 1935, Agenesie complete de la commissure calleuse et troubles du developpement de l’ hémisphère gauche avec hémiparésie droite et intégrité mentale, Schweiz Arch Neurol Neurochirur Psychiatr 35: 64–80.
Diebler, C., and Dulac, O., 1987, “Pediatric Neurology and Neuroradiology: Cerebral and Cranial Diseases”, Springer-Verlag, Berlin, New York.
Diebler, C., and Ponsot, G., 1983, Hamartomas of the tuber cinereum, Neuroradiology 25: 93–102.
Friedma, M., and Cohen P., 1947, Agenesis of the corpus callosum as a possible sequel to maternal rubella during pregnancy, Am J Dis Child 73: 178–185.
Jones, K. L., and Smith, D. W., 1973, Recognition of the fetal alcohol syndrome in early infancy, Lancet ii: 999–1001.
Josephy, M., 1944, Congenital agyria and defect of corpus callosum, J Neuropathol Exp Neurol 3: 63–68.
Kaplan, P., 1983, X-linked recessive inheritance of agenesis of the corpus callosum, J Med Genet 20: 122–124.
Kazner, E., Stochdorph, O., Wende, S., et al., 1980, Intracranial lipoma, J Neurosurg 52: 234–245.
Probst, F. P., 1979, “The Prosencephalies”, Springer, Berlin, Heidelberg, New York.
Santanelli, P., Bureau, M., Magaudda, A., Gobbi, G., and Roger, J., 1989, Benign partial epilepsy with centrotemporal (or Rolandic) spikes and brain lesion, Epilepsia 30: 182–188.
Townes, P. L., Wood, B. P., and McDonald, J. V., 1976, Further heterogeneity of the oral-facial digital syndromes, Am J Dis Child 130: 548–554.
Van Epps, E. F., 1953, Agenesis of the corpus callosum with concomitant malformations, including atresia of the foramen of Luschka and Magendi, Am J Roentgenol 70: 47–60.
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© 1994 Springer Science+Business Media New York
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Dulac, O., Diebler, C. (1994). Agenesis of the Corpus Callosum. In: Shorvon, S.D., Fish, D.R., Andermann, F., Bydder, G.M., Stefan, H. (eds) Magnetic Resonance Scanning and Epilepsy. NATO ASI Series, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2546-2_18
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DOI: https://doi.org/10.1007/978-1-4615-2546-2_18
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