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The Significance of T2 Changes in the Hippocampus

  • P. Tofts
Part of the NATO ASI Series book series (NSSA, volume 264)

Abstract

Relaxation times T1 and T2 can be measured accurately and reproducibly in the brain (Tofts and Du Boulay, 1990), enabling white matter in different disease groups to be differentiated (Miller et al., 1989). However, scanner performance can degrade both accuracy and reproducibility, and the pathological cause of changes in relaxation times has yet to be established with certainty.

Keywords

Relaxation Time White Matter Central Nervous System Disease Magnetisation Transfer Nuclear Magnetic Resonance Relaxation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barker, G., and Tofts, P. S., 1992, Semiautomated quality assurance for quantitative magnetic resonance imaging, Magn Reson Imag. 10: 585–595.CrossRefGoogle Scholar
  2. Bottomley, P. A., Hardy, C. J., Argersinger, R. E., and Allen-Moore, G., 1987, A review of 1H nuclear magnetic resonance relaxation in pathology: Are Tl and T2 diagnostic?, Med Phys. 14: 1–37.PubMedCrossRefGoogle Scholar
  3. Lerski, R. A., and McRobbie, D. W., 1992, Instructions for Eurospin II Magnetic Resonance Quality Assessment Test Objects, Diagnostic Sonar Ltd, Livingston.Google Scholar
  4. Miller, D. H., Johnson, G., Tofts, P. S., Macmanus, D., and McDonald, W. I., 1989, Precise relaxation time measurements of normal appearing white matter in inflammatory central nervous system disease, Magn Reson Med. 11: 331–336.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • P. Tofts
    • 1
  1. 1.Institute of NeurologyLondonUK

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