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Dietary Fatty Acids and Human Breast Cancer Cell Growth, Invasion, and Metastasis

  • David P. Rose
  • Jeanne M. Connolly
  • Xin-Hua Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 364)

Abstract

There is considerable interest in the utilization of a low-fat dietary intervention to reduce the risk of recurrence in postsurgical breast cancer patients with potentially curable disease.1-5 This concept developed initially from epidemiological and clinical studies, reviewed elsewhere,5-6 but it gained support from investigations utilizing experimental animal models. Prominent among these was the work of Erickson and colleagues, who showed that feeding a high-fat diet rich in linoleic acid (LA), an omega-6 polyunsaturated fatty acid, enhanced metastasis of a mouse mammary tumor cell line, compared with a diet containing the same {tiyquantity} of fat, but low in LA content. Similar results were obtained by Katz and Boylan8 with a transplantable, metastasizing, rat mammary carcinoma, but with diets containing either 20% or 5% (wt/wt) corn oil, a lipid source rich in LA.

Keywords

Breast Cancer Linoleic Acid Human Breast Cancer Cell Human Breast Cancer Cell Line Female Athymic Nude Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • David P. Rose
    • 1
  • Jeanne M. Connolly
    • 1
  • Xin-Hua Liu
    • 1
  1. 1.Division of Nutrition and EndocrinologyAmerican Health FoundationValhallaUSA

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