Dietary Fatty Acids and Human Breast Cancer Cell Growth, Invasion, and Metastasis

  • David P. Rose
  • Jeanne M. Connolly
  • Xin-Hua Liu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 364)


There is considerable interest in the utilization of a low-fat dietary intervention to reduce the risk of recurrence in postsurgical breast cancer patients with potentially curable disease.1-5 This concept developed initially from epidemiological and clinical studies, reviewed elsewhere,5-6 but it gained support from investigations utilizing experimental animal models. Prominent among these was the work of Erickson and colleagues, who showed that feeding a high-fat diet rich in linoleic acid (LA), an omega-6 polyunsaturated fatty acid, enhanced metastasis of a mouse mammary tumor cell line, compared with a diet containing the same {tiyquantity} of fat, but low in LA content. Similar results were obtained by Katz and Boylan8 with a transplantable, metastasizing, rat mammary carcinoma, but with diets containing either 20% or 5% (wt/wt) corn oil, a lipid source rich in LA.


Breast Cancer Linoleic Acid Human Breast Cancer Cell Human Breast Cancer Cell Line Female Athymic Nude Mouse 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • David P. Rose
    • 1
  • Jeanne M. Connolly
    • 1
  • Xin-Hua Liu
    • 1
  1. 1.Division of Nutrition and EndocrinologyAmerican Health FoundationValhallaUSA

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