Some Aspects of Vitamin E Related to Humans and Breast Cancer Prevention

  • Nikolay V. Dimitrov
  • Rui-Qin Pan
  • Jan Bauer
  • Thomas I. Jones
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 364)


Vitamin E is widely recognized as a lipotrophic antioxidant which plays an important role in the chain of events that protect biological membranes against injury from a variety of oxidant agents.1–3 Free radicals provide strongly reactive oxygen in the tissues and can be formed endogenously by normal metabolic process or exogenously by factors external to the body. These chemical reaction lead directly to cell and tissue damage and are thus thought to initiate or promote neoplasia. It has been suggested that vitamin E can inhibit this process.2–4 The biological action of vitamin E and the correct evaluation of nutritional status of this micronutrient depend substantially on its kinetics and dynamics in body tissues. Besides the well-characterized function of vitamin E as an antioxidant, other roles such as a regulator of membrane fluidity,5 a membrane stabilizer6 and inhibitor of 5-lipoxygenase activity7 have been demonstrated. Although the exact machanism of its action is not fully understood, there is more evidence for participating of vitamin E in regulation of growth differentiation and transformation of mammalian cells.8,9 All these biological activities could be related to the carcinogenic process, and results from animal studies have demonstrated the anticarcinogenic effect of vitamin E in tumors induced by various initiators and promoters.10,11


Breast Cancer Adipose Tissue Ductal System Breast Tumor Tissue Tocopherol Concentration 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Nikolay V. Dimitrov
    • 1
  • Rui-Qin Pan
    • 2
  • Jan Bauer
    • 3
  • Thomas I. Jones
    • 1
  1. 1.Department of MedicineMichigan State UniversityEast LansingUSA
  2. 2.Department of SurgeryChina-Japan Friendship HospitalBeijingChina
  3. 3.Department of OncologyCharles UniversityPragueCzech Republic

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