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Vitamin D and Breast Cancer

  • Sylvia Christakos
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 364)

Abstract

  1. 1.

    1,25-Dihydroxyvitamin D3, the biologically active form of vitamin D, in addition to regulating calcium homeostasis, also has antiproliferative and prodifferentiating effects.

     
  2. 2.

    Most studies concerning the therapeutic potential of analogs of 1,25(OH)2D3, which are antiproliferative and prodifferentiating but do not cause hypercalcemia, have been done using leukemic cells.

     
  3. 3.

    Recent evidence from both in vivo and {tiin vitro} studies has indicated that 1,25(OH)2D3 or analogs of 1,25(OH)2D3 can inhibit the growth of breast cancer cells, thus suggesting the therapeutic potential of analogs of 1,25(OH)2D3 in the treatment of breast cancer.

     

Keywords

Breast Cancer Acute Myeloid Leukemia Intestinal Calcium Absorption Side Chain Length Human Promyelocytic Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Reichel, H., H.P. Koeffler, and A.W. Norman, The role of the vitamin D endocrine system in health and disease, N. Engl. J. Med. 320:980 (1989).PubMedCrossRefGoogle Scholar
  2. 2.
    Abe, E., C. Miyaura, H. Sakagami, M. Takeda, K. Konno, T. Yamazaki, S. Yoshiki, and T. Suda, Differentiation of mouse myeloid leukemia cells induced by lά,25-dihydroxy-vitamin D3, Proc. Natl. Acad. Sci. USA 78:4990 (1981).PubMedCrossRefGoogle Scholar
  3. 3.
    Munker, R., A.W. Norman, and H.P. Koeffler, Vitamin D compounds: effect on clonal proliferation and differentiation of human myeloid cells, J. Clin. Invest. 78:424 (1986).PubMedCrossRefGoogle Scholar
  4. 4.
    Koeffler, H.P., K. Hirji, and L. Itri, 1,25-Dihydroxyvitamin D3: in vivo and in vitro effect on human preleukemic and leukemic cells, Cancer Treat. Rep. 69:1399 (1985).PubMedGoogle Scholar
  5. 5.
    Dodd, R.C., M.S. Cohen, S.L. Newman, and T.K. Gray, Vitamin D metabolites change the phenotype of monoblastic U937 cells, Proc. Natl. Acad. Sci. USA 80:7538 (1983).PubMedCrossRefGoogle Scholar
  6. 6.
    Tanaka, H., E. Abe, C. Miyaura, Y. Shiina, and T. Suda, lά,25-Dihydroxyvitamin D3 induces differentiation of human promyelocytic leukemia cells (HL-60) into monocyte-macrophages but not into granulocytes, Biochem. Biophys. Res. Commun. 117:86 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    Simpson, R.U., T. Hsu, D.A. Begley, B.S. Mitchell, and B.N. Alizadeh, Transcriptional regulation of the c-myc protooncogene by 1,25-dihydroxyvitamin D3 in HL-60 promyelocytic leukemia cells, J. Biol. Chem. 262:4104 (1987).PubMedGoogle Scholar
  8. 8.
    Brevli, Z.S. and G.P. Studzinksi, Changes in the expression of oncogenes encoding nuclear phosphoproteins but not c-Ha-ras have a relationship to monocytic differentiation of HL60 cells, J. Cell. Biol. 102:2234 (1986).CrossRefGoogle Scholar
  9. 9.
    Ostrem, V.K., Y. Tanaka, J. Prahl, H.R DeLuca, and N. Ikekawn, 24-and 26-homo-l,25-dihydroxyvitamin D3: preferential activity in inducing differentiation of human leukemia cells HL-60 in vitro, Proc. Natl. Acad. Sci. USA 84:2610 (1987).PubMedCrossRefGoogle Scholar
  10. 10.
    Perlman, K., A. Kutner, J. Prahl, C. Smith, M. Inaba, H.K. Schnoes, and H.F. DeLuca, 24 Homologated 1,25-dihydroxyvitamin D3 compounds: separation of calcium and cell differentiation activities, Biochemistry 29:190 (1990).PubMedCrossRefGoogle Scholar
  11. 11.
    Zhou, J.Y., A.W. Norman, M. Lubbert, E.D. Collins, M.R. Uskokovic, and H.P. Koeffler, Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone calcium mobilization, Blood 74:82 (1989).PubMedGoogle Scholar
  12. 12.
    Zhou, J.Y., A.W. Norman, D.-L. Chen, G.-W. Sun, M. Uskokovic, and H.P. Koeffler, 1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice, Proc. Natl. Acad. Sci. USA 87:3929 (1990).PubMedCrossRefGoogle Scholar
  13. 13.
    Abe, J., M. Morikawa, K. Miyamoto, S. Kaiho, M. Fukushima, C. Miyaura, E. Abe, T. Suda, and Y. Nishii, Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton, FEBS Lett. 226:58 (1987).PubMedCrossRefGoogle Scholar
  14. 14.
    Wang, Y.-Z., H. Li, M.E. Bruns, M. Uskokovic, G.A. Truitt, R. Horst, T. Reinhardt, and S. Christakos, Effect of 1,25,28-trihydroxyvitamin D2 and 1,24,25-trihydroxyvitamin D3 on intestinal calbindin-D9k mRNA and protein: is there a correlation with intestinal calcium transport?, J. Bone Min. Res. 8:1483 (1993).CrossRefGoogle Scholar
  15. 15.
    Colston, K., M.J. Colston, and D. Feldman, 1,25-Dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture, Endocrinology 108:1083(1981).PubMedCrossRefGoogle Scholar
  16. 16.
    Frampton, R.J., S.A. Omond, and J.A. Eisman, Inhibition of human cancer cell growth by 1,25-dihydroxy vitamin D3 metabolites, Cancer Res. 43:4443 (1983).PubMedGoogle Scholar
  17. 17.
    Eisman, J.A., T.J. Martin, I. MacIntyre, and J.M. Moseley, 1,25-Dihydroxyvitamin D3 receptors in breast cancer cells, Lancet ii:1335 (1979).CrossRefGoogle Scholar
  18. 18.
    Brehier, A. and M. Thomassett, Human colon cell line HT-29: characterization of 1,25-dihydroxyvitamin D3 receptor and induction of differentiation by the hormone, J. Steroid Biochem. 29:265 (1988).PubMedCrossRefGoogle Scholar
  19. 19.
    Colston, K.W., U. Berger, and R. C. Coombes, Possible role for vitamin D in controlling breast cancer cell proliferation, Lancet i:188 (1989).CrossRefGoogle Scholar
  20. 20.
    Colston, K.W., A.G. Mackay, S.Y. James, L. Binderup, S. Chander, and R.C. Coombes, EB 1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro, Biochem. Pharmacol. 44:2273 (1992).PubMedCrossRefGoogle Scholar
  21. 21.
    Abe, J., T. Nakano, Y. Nishii, T. Matsumoto, E. Ogata, and K. Ikeda, A novel vitamin D3 analog, 22-oxa-l,25-dihydroxyvitamin D3 inhibits growth of human breast cancer in vitro and in vivo without causing hypercalcemia, Endocrinology 129:832 (1991).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Sylvia Christakos
    • 1
  1. 1.Department of Biochemistry and Molecular Biology, New Jersey Medical SchoolUniversity of Medicine and Dentistry of New JerseyNewarkUSA

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