Selection of Anti-Arsonate Idiotype (CRIA) in A/J Mice by the Immune Network
A/J mice immunized against arsonate (ARS) coupled to hemocyanin (KLH) synthesize a cross reactive idiotype named CRIA (Kuettner et al., 1972). This idiotype is encoded by a single combination of genes called the canonical combination which is constituted of one VH gene (VHIdCR11), one D segment (DFL16.1), one JH segment (JH2), one VK gene (VKIdCR) and one JK segment (JK1).
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- Ryelandt, M., De Wit, D., Baz, A., et al., 1993, The perinatal presence of antigen (p-azophenylarsonate) leads to the loss of the recurrent idiotype (CRIA) in A/J mice, submitted.Google Scholar