Abstract
A/J mice immunized against arsonate (ARS) coupled to hemocyanin (KLH) synthesize a cross reactive idiotype named CRIA (Kuettner et al., 1972). This idiotype is encoded by a single combination of genes called the canonical combination which is constituted of one VH gene (VHIdCR11), one D segment (DFL16.1), one JH segment (JH2), one VK gene (VKIdCR) and one JK segment (JK1).
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References
Kuttner, M.G., Wang, A., and Nisonoff, A., 1972, Quantitative investigations of idiotypic antibodies, J. Exp. Med. 135:579.
Manser, T., Wysocki, M., Margolies, N., and Gefter, M.L., 1987, Evolution of antibody variable structure during the immune response, Immunol. Rev. 96:141.
Leo, O., Slaoui, M., Marvel, J., et al., 1985, Idiotypic analysis of polyclonal and monoclonal anti-p-azophenylarsonate antibodies of BALB/c mice expressing the major cross-reactive idiotype of the A/J strain, J. Immunol. 134:1734.
Jeske, D., Milner, E.C.B., Leo, O., Moser, M., Marvel, J., Urbain, J., and Capra, J.D., 1986, Molecular mapping of idiotopes of anti-arsonate antibodies, J. Immunol. 136:2568.
Hasemann, C, and Capra, J.D., 1991, Mutational analysis of the crossreactive idiotype of the A strain, J. Immunol. 147:3170.
Manser, T., Huang, S.Y., and Gefter, M.L., 1984, Influence of clonal selection on the expression of immunoglobulin variable region gene, Science 226:1283.
Willems, F., Vansantem, G., De Wit, D., Slaoui, M., and Urbain, J.,1990, Loss of a major idiotype (CRIA) after repopulation of irradiated mice, J. Immunol. 144:1396.
Gaya, A., Alsinet, E., Freixas, M., and Vives, J., 1988, Change in idiotypic predominance in the anti-arsonate response by priming with anti-idiotypic antibodies, Scand. J. Immunol. 28:331.
Linton, P.J., Decker, D., and Klinman, N., 1989, Primary antibody forming cells and secondary B cells are generated from separate precursor cell subpopulations, Cell 59:1049.
Ryelandt, M., De Wit, D., Baz, A., et al., 1993, The perinatal presence of antigen (p-azophenylarsonate) leads to the loss of the recurrent idiotype (CRIA) in A/J mice, submitted.
Urbain, J., Andris, F., Brait, M., et al., 1989, Self-nonself discrimination in the immune system: a broken idiotypic mirror, in the Molecular Basis of the Immune Response. Ed. Bona, C, Ann. N.Y. Acad. of Sci. 546:43.
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© 1994 Springer Science+Business Media New York
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Brait, M. et al. (1994). Selection of Anti-Arsonate Idiotype (CRIA) in A/J Mice by the Immune Network. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_8
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DOI: https://doi.org/10.1007/978-1-4615-2492-2_8
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