Non-Lymphoid Cells in Acute and Chronic Experimental Inflammatory Bowel Disease

  • Mary J. H. J. Palmen
  • Marja B. van der Ende
  • A. Salvador Peña
  • Emmelien P. van Rees
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 355)


The etiology of inflammatory bowel disease (IBD), like Crohn’s disease and ulcerative colitis remains unclear. A recurrent theme is a failure to down-regulate a local hyperreactive immune response. Autoimmunity possibly plays a role as circulating antibodies reactive against a protein in colonie epithelial cells are found in patients with ulcerative colitis (Takahasi et al., 1990). Local non-lymphoid cells like macrophages, dendritic cells and epithelial cells could be important in IBD in the pathogenesis and in the uptake and processing of antigen in affected tissue, leading to secondary bacterial infection.


Dendritic Cell Inflammatory Bowel Disease Ulcerative Colitis Lamina Propria Colonic Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mary J. H. J. Palmen
    • 1
  • Marja B. van der Ende
    • 1
  • A. Salvador Peña
    • 1
  • Emmelien P. van Rees
    • 1
  1. 1.Department of Cell Biology, Div. Histology Department of Gastroenterology Faculty of MedicineFree University Van der BoechorststraatAmsterdamThe Netherlands

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