Non-Lymphoid Cells in Acute and Chronic Experimental Inflammatory Bowel Disease
The etiology of inflammatory bowel disease (IBD), like Crohn’s disease and ulcerative colitis remains unclear. A recurrent theme is a failure to down-regulate a local hyperreactive immune response. Autoimmunity possibly plays a role as circulating antibodies reactive against a protein in colonie epithelial cells are found in patients with ulcerative colitis (Takahasi et al., 1990). Local non-lymphoid cells like macrophages, dendritic cells and epithelial cells could be important in IBD in the pathogenesis and in the uptake and processing of antigen in affected tissue, leading to secondary bacterial infection.
KeywordsDendritic Cell Inflammatory Bowel Disease Ulcerative Colitis Lamina Propria Colonic Epithelial Cell
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- Damoiseaux, J.G.M.C. Döpp, E.A, Neefjes, J.J., Beelen, R.HJ. and Dijkstra, CD., 1989, Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kD (CD11/CD18), J. Leuk. Biol. 46: 556.Google Scholar
- Sartor, R.B., Bender, D.E., Allen, J.B., Zimmermann, E.M., Holt, L.C., Pardo, M.S., Lund, P.K., Wahl, S.M., 1993, Chronic experimental enterocolitis and extraintestinal inflammation are T lymphocyte dependent, Gastroenterology 104, no.4: A 775.Google Scholar
- Shappel, S.B., Toman, C, Anderson, D.C, Taylor, A.A., Entman, M.L. and Smith, C.W., 1990, Mac-1 (CD11b/CD 18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils, J. Immunol. 144: 2702.Google Scholar
- Von Asmuth, E.J.U., Van der Linden, C.J., Leeuwenberg, J.F.M. and Buurman, W.A., 1991, Involve ment of the CD 11b/CD 18 integrin, but not of the endothelial cell adhesion molecules ELAM-1 and ICAM-1 in tumor necrosis factor-induced neutrophil toxicity, J. Immunol. 147: 3869.Google Scholar
- Wilders, M.M., Drexhage, H.A., Kokje, M., Verspaget, H.W., Meuwissen, S.G.M., 1984, Veiled cells in chronic idiopathic inflammatory bowel disease, Clin. Exp. Imm. 55: 461–468.Google Scholar
- Wright, S.D., Rao, P.E., Van Vorrhis, W.C., Craigmyle L.S., Iida, K., Talle, M.A., Westberg, E.F., Goldstein, G. and Silverstein, S.C, 1983, Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies, Proc. Natl. Acad. Sci. USA. 80: 5699.PubMedCrossRefGoogle Scholar