Advertisement

Non-Lymphoid Cells in Acute and Chronic Experimental Inflammatory Bowel Disease

  • Mary J. H. J. Palmen
  • Marja B. van der Ende
  • A. Salvador Peña
  • Emmelien P. van Rees
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 355)

Abstract

The etiology of inflammatory bowel disease (IBD), like Crohn’s disease and ulcerative colitis remains unclear. A recurrent theme is a failure to down-regulate a local hyperreactive immune response. Autoimmunity possibly plays a role as circulating antibodies reactive against a protein in colonie epithelial cells are found in patients with ulcerative colitis (Takahasi et al., 1990). Local non-lymphoid cells like macrophages, dendritic cells and epithelial cells could be important in IBD in the pathogenesis and in the uptake and processing of antigen in affected tissue, leading to secondary bacterial infection.

Keywords

Dendritic Cell Inflammatory Bowel Disease Ulcerative Colitis Lamina Propria Colonic Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Allison, M.C., Cornwall, S., Poulter, L.W., Dhillon, A.P., Pounder, R.E., 1988, Macrophage heterogeneity in normal colonie mucosa and in inflammatory bowel disease, Gut 29: 1531–1538.PubMedCrossRefGoogle Scholar
  2. Damoiseaux, J.G.M.C. Döpp, E.A, Neefjes, J.J., Beelen, R.HJ. and Dijkstra, CD., 1989, Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kD (CD11/CD18), J. Leuk. Biol. 46: 556.Google Scholar
  3. Dijkstra, C.D., Döpp, E.A., Joling, P., Kraal, G., 1985, The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3, Immunology 54: 589.PubMedGoogle Scholar
  4. Henson, P.M. and Johnson, R.B., 1987, Tissue injury in inflammation. J. Clin. Invest. 79: 669–674.PubMedCrossRefGoogle Scholar
  5. Huitinga, I., Damoiseaux, J.G.M.C, Döpp, E.A. and Dijkstra, C.D., 1993, Treatment with anti-CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rat, Eur. J. Immunol. 23: 709–715.PubMedCrossRefGoogle Scholar
  6. Hynes, R.O., 1987, Integrins: A family of cell surface receptors, Cell 48: 549.PubMedCrossRefGoogle Scholar
  7. Malizia, G., Calabrese, A., Cottone, M., Raimondo, M., Trejdosiewicz, L.K., Smart, C.J., Oliva, L. and Pagliaro, L., 1991, Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease, Gastroenterology 100: 150.PubMedGoogle Scholar
  8. Mayer, L.D., Eisenhardt, D., Salomon, P., Bauer, W., Pious, R. and Piccinini, L., 1991, Expression of class II molecules on intestinal epithelial cells in humans: difference between normal and IBD, Gastroenterology 100: 3.PubMedGoogle Scholar
  9. Morris, G.P., Beck, P.L., Herridge, M.S., Depew, W.T., Szewczuk, M.R., Wallace, J.L., 1989, Hapten-i induced model of chronic inflammation and ulcération in the rat colon, Gastroenterology 96: 795–803.PubMedGoogle Scholar
  10. Pavli., Woodhams, C.E., Doe, W.F., Hume, D.A., 1990, Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria, Immunology 70: 40–47.PubMedGoogle Scholar
  11. Sartor, R.B., Bender, D.E., Allen, J.B., Zimmermann, E.M., Holt, L.C., Pardo, M.S., Lund, P.K., Wahl, S.M., 1993, Chronic experimental enterocolitis and extraintestinal inflammation are T lymphocyte dependent, Gastroenterology 104, no.4: A 775.Google Scholar
  12. Schmitt, M., Mussel, H.H. and Dierich, M.P., 1981, Qualitative and quantitative assessment of C3-receptor reactivities on lymphoid and phagocytic cells, J. Immunol. 126: 2042.PubMedGoogle Scholar
  13. Seldenrijk, C.A., Drexhage, H.A., Meuwissen, S.G.M., Pals, S.T., Meijer, C.J.L.M., 1989, Dendritic cells and scavenger macrophages in chronic inflammatory bowel disease, Gut 30: 484.PubMedCrossRefGoogle Scholar
  14. Shappel, S.B., Toman, C, Anderson, D.C, Taylor, A.A., Entman, M.L. and Smith, C.W., 1990, Mac-1 (CD11b/CD 18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils, J. Immunol. 144: 2702.Google Scholar
  15. Takahasi, F., Shah, H.S., Wise, L.S., Das, K.M., 1990, Circulating antibodies against human colonic extract enriched with a 40 kD protein in patients with ulcerative colitis, Gut 31: 1016–1020.PubMedCrossRefGoogle Scholar
  16. Von Asmuth, E.J.U., Van der Linden, C.J., Leeuwenberg, J.F.M. and Buurman, W.A., 1991, Involve ment of the CD 11b/CD 18 integrin, but not of the endothelial cell adhesion molecules ELAM-1 and ICAM-1 in tumor necrosis factor-induced neutrophil toxicity, J. Immunol. 147: 3869.Google Scholar
  17. Wilders, M.M., Drexhage, H.A., Kokje, M., Verspaget, H.W., Meuwissen, S.G.M., 1984, Veiled cells in chronic idiopathic inflammatory bowel disease, Clin. Exp. Imm. 55: 461–468.Google Scholar
  18. Wright, S.D., Rao, P.E., Van Vorrhis, W.C., Craigmyle L.S., Iida, K., Talle, M.A., Westberg, E.F., Goldstein, G. and Silverstein, S.C, 1983, Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies, Proc. Natl. Acad. Sci. USA. 80: 5699.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Mary J. H. J. Palmen
    • 1
  • Marja B. van der Ende
    • 1
  • A. Salvador Peña
    • 1
  • Emmelien P. van Rees
    • 1
  1. 1.Department of Cell Biology, Div. Histology Department of Gastroenterology Faculty of MedicineFree University Van der BoechorststraatAmsterdamThe Netherlands

Personalised recommendations