Abstract
Recently the various compartments of the chicken spleen were investigated for their role during the induction and effector phase of the humoral immune response against T-cell dependent antigens (1). In general, all events in the chicken spleen occurred at similar timepoints and at similar sites as they do in the mammalian spleen. For example, antigen-specific antibody-containing cells were first detected in peri-arteriolar T cell sheaths (PALS) and later in the red pulp (2). The induction of the response was found to occur in the complex of ellipsoid, peri-ellipsoid B lymphocyte sheath (PELS) and surrounding macrophages, which is therefore the functional analogue of the mammalian marginal zone with its sinus, B lymphocytes and non-lymphoid cells (3).
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References
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© 1994 Springer Science+Business Media New York
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Jeurissen, S.H.M., Janse, E.M. (1994). Germinal Centers Develop at Predilicted Sites in the Chicken Spleen. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_40
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DOI: https://doi.org/10.1007/978-1-4615-2492-2_40
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