Abstract
The nonobese diabetic (NOD) mouse spontaneously develops insulin-dependent diabetes mellitus as a result of autoimmune destruction of β-cells in the pancreatic islets of Langerhans. It is thus widely accepted as a relevant experimental model for human type I diabetes 1–3. Clinically-defined disease occurs more predominantly in females and can be observed from the age of 3 months. Insulitis always precedes the onset of diabetes, but appears in both males and females from the age of 3–4 weeks4–5.
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References
J.F. Bach, and C. Boitard, Experimental models of type-I diabetes. Pathol. Immunopathol. Res. 5:384 (1986)
H. Kolb, Mouse models of insulin-dependent diabetes: low-dose streptozotocin-induced diabetes and nonobese diabetic (NOD) mice. Diabetes Metab. Rev. 3:751 (1987)
E.H. Leiter, M. Prochaska, and D.L. Coleman, The non-obese diabetic (NOD) mouse. Am. J. Pathol. 128:380 (1987)
S. Makino, K. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri, and Y. Tochino. Breeding of a non-obese, diabetic strain of mice. Exp. Anim. 29:1 (1980)
E.F. Lampeter, A. Signore, E.A. Gale, and P. Pozzilli. Lessons from the NOD mouse for the pathogenesis and immunotherapy of human type 1 (insulin-dependent) diabetes mellitus. Diabetologia 32:703 (1989)
L.S. Wicker, B J. Miller, and Y. Mullen. Transfer of autoimmune diabetes mellitus with splenocytes from onobese diabetic (NOD) mice. Diabetes 35:855 (1986)
A. Bendelac, C. Carnaud, C. Boitard, and J.F. Bach. Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requiement for both L3T4+ and Lyt-2+ T-cells. J. Exp. Med. 166:823 (1987)
M. Ogawa, T. Maruyama, T. Hasegawa, T. Kanaya, F. Kobayashi, Y. Tochino, and H. Uda. The inhibitory effect of neonatal thymectomy on theincidence of insulitis in non-obese diabetic (NOD) mice. Biomed. Res 6:103(1985)
M. Dardenne, F. Lepault, A. Bendelac, and J.F.Bach. Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning. Eur. J. Immunol. 19:889 (1989)
W. Savino, C. Boitard, J.F. Bach, and M. Dardenne. Studies on the thymus in nonobese diabetic mouse. I. Changes in the microenvironmental compartments. Lab. Invest. 64:405 (1991)
W. Savino, C. Carnaud, J.J. Luan, J.F. Bach, and M. Dardenne. Characterization of the extracellular matrix-containing giant perivascular spaces in the NOD mouse thymus. Diabetes 42:134 (1993)
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© 1994 Springer Science+Business Media New York
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Savino, W., Carnaud, C., Dardenne, M. (1994). Characterization of Giant Perivascular Spaces in the Thymus of the Nonobese Diabetic Mouse. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_24
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DOI: https://doi.org/10.1007/978-1-4615-2492-2_24
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