Abstract
The NOD mouse is an experimental model for human autoimmune type I diabetes, in which lymphocyte infiltration (insulitis) into the islets of Langerhans develops from 3-5 weeks of age in both sexes while overt diabetes occurs predominantly in females from 12 weeks of age1. The central role of T cells in insulin-secreting beta cell destruction has been widely documented 2–5. However, the mechanisms of lymphocyte infiltration are still unclear.
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S. Makino, K. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri and Y. Tochino, Breeding of a non-obese, diabetic strain of mice, Exp. Anim. 29:1 (1980).
A. Miyazaki, T. Hanafusa, K. Yamada, J. Miyagawa, H. Fujino-Kurihara, H. Nakajima, K. Nonaka and S. Tarai, Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study, Clin. Exp. Immunol. 60:622 (1985).
M. Ogawa, T. Maruyama and T. Hasegawa, The inhibitory effect of neonatal thymectomy on the incidence of insulitis in non-obese diabetic (NOD) mice, Biomed. Res. 6:103 (1985).
Y. Mori, M. Suko and H. Odudaira, Preventive effects of cyclosporin on diabetes in NOD mice, Diabetologia 29: 244 (1986).
A. Bendelac, C. Carnaud, C. Boitard and J.F. Bach, Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells, J. Exp. Med. 166: 823 (1987).
W.M. Gallatin, I.L. Weissman and E.C. Butcher, A cell surface molecule involved in organ-specific homing of lymphocytes, Nature 304: 30 (1983).
B. Holzmann, B.W. McIntyre, and I.L. Weissman, Identification of a murine Peyer’s patch-specific lymphocyte homing as an integrin molecule with an alpha chain homologous to human VLA-4 alpha, Cell 56: 37 (1989).
A. Hamann, D. Jablonskli-Westrich, A. Duijvestijin, E.C. Butcher, H. Baisch, R. Harder and H. Tiele, Evidence for an accessory role of LFA-1 in lymphocyte-high endothelium interaction during homing, J. Immunol. 140: 693 (1988).
S. Jalkanen, R.F. Bargatze, J. de Los Togos and E.C. Butcher, Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85-95-kD glycoprotein in antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells, J. Cell. Biol. 105: 983 (1987).
P.R. Streeter, B.T.N. Rouse and E.C. Butcher, Immunohistologic and functional characterization of a vascular addressin involved in lymphocyte homing into peripheral lymph nodes, J. Cell. Biol. 107: 1853 (1988).
Y. Shimisu, W. Newman, Y. Tanaka and S. Shaw, Lymphocyte interactions with endothelial cells, Immunol. Today 13:106 (1992).
A. Hänninen, S. Jalkanen, M. Salmi, S. Toikkanen, G. Nikolakaros and O. Simell, Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus, J. Clin. Invest. 90:1901 (1992).
M. Patarroyo, Leukocyte adhesion in host defense and tissue injury, Clin. Immunol. Immunopathol. 60: 333 (1991).
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© 1994 Springer Science+Business Media New York
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Faveeuw, C., Gagnerault, MC., Lepault, F. (1994). Modifications of the Expression of Homing and Adhesion Molecules in Infiltrated Islets of Langerhans in Nod Mice. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_23
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DOI: https://doi.org/10.1007/978-1-4615-2492-2_23
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