Abstract
Communication between the neuroendocrine and immune system is crucial to host defence in both health and disease for it provides a means whereby the central nervous system may fine tune the immune system and thereby bring to bear the influence of a variety of physical, emotional and environmental factors. Several lines of evidence now suggest that humoral factors originating within the immune system (e.g. cytokines, ecosanoids and peptides) exert specific regulatory actions within the brain and pituitary gland, whilst neural and endocrine factors contribute to the control of immunological activity (Weigent and Blalock, 1987). Central to this communication are the thymic hormones, thymulin, thymosinαl and thymopoietin which provide the basis of the humoral link between the thymus and the hypothalamo-pituitary complex and are themselves subject to regulation by hormones derived from the pituitary gland and peripheral endocrine organs (Millington and Buckingham, 1992).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Buckingham, J.C., Safieh, B., Singh, S., Arduino, L.A., Cover, P.O. and Kendall, M.D., 1992, Interactions between the hypothalamo-pituitary adrenal axis and the thymus in the rat: a role for corticotrophin in the control of thymulin release. J. Neuroendocrinol. 4:295–301.
Dardenne M., Charreire, J. and Bach, J.F., 1978, Alterations in thymocyte surface markers after in vivo treatment by serum thymic factor. Cell. Immunol. 39:47–54.
Dardenne, M. and Savino, W., 1990, Neuroendocrine control of the thymic epithelium: modulation of thymic endocrine function, cytokine expression and cell proliferation by hormones and peptides. Prog. NeuroEndocrinlmmunol. 3:18–25.
DeTogni, P., Niman, H., Raymond, V., Sawchenko, P. and Verma, I.M. 1988, Detection of fos protein during osteogenesis by monoclonal antibodies. Mol. Cell Biol. 8:2251–2256.
Kendall, M.D., Safieh, B., Sareen, A., Venn, G., Matheson, L. and Ritter, M., 1991, Thymulin secreting cells in man: distribution, LM histochemistry and plasma thymulin levels, in Lymphatic Tissues and in vivo Immune Responses,” B.A. Imhof, S. Berrih-Aknin and S. Ezine, Dekker New York.
Kendall, M.D., Safieh, B., Buckingham, J.C. and Ritter, M.A., 1992, A rise in plasma thymulin alters thymocyte phenotype. Neuroimmunomodulation in Pharmacology 2nd Course of the Fed. Europ. Pharmacol. Socs., Paris, Feb. 5–7.
Moody, C, Dashwood, M.R., Sykes, R.M. et al., 1990, Functional and autoradiographic evidence for endothelin receptors on human and rat cardiac myocytes: comparison with single smooth muscle cells. Circ. Res. 67:764–769.
Millington, G. and Buckingham, J.C, 1992, Thymic peptides and neuroendocrine-immune communication. Curr. Sep. 10:Abs 41,98–99.
Weigent D. and Blalock E., 1987, Interactions between the neuroendocrine and immune systems: common hormones and recptors. Immunol. Rev. 100:79–108.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kendall, M.D., Loxley, H.D., Dashwood, M.R., Singh, S., Stebbings, R., Buckingham, J.C. (1994). Could Acth be of Prime Importance in Rapidly Altering the Thymocyte Composition in the Thymus?. In: Heinen, E., Defresne, M.P., Boniver, J., Geenen, V. (eds) In Vivo Immunology. Advances in Experimental Medicine and Biology, vol 355. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2492-2_18
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2492-2_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6062-9
Online ISBN: 978-1-4615-2492-2
eBook Packages: Springer Book Archive