Clinical Approach to the Compromised Host with Fever and Pulmonary Infiltrates

  • Robert H. Rubin
  • Reginald Greene

Abstract

The immunocompromised patient in whom fever and pneumonitis develop presents a formidable challenge to the clinician. On one hand, a legion of microbial invaders, ranging from common viral and bacterial pathogens to exotic fungal and protozoan agents, have been reported to cause pulmonary infection in these patients. 1-8 On the other hand, noninfectious causes of pulmonary inflammation—radiation lung injury, drug reactions, the underlying neoplasm, pulmonary embolic disease, leukoagglutinin transfusion reactions, pulmonary hemorrhage, atypical pulmonary edema, and alveolar proteinosis— may present a clinical picture similar to that produced by infection (i.e., the febrile pneumonitis syndrome).2,3,5,9-11

Keywords

Corticosteroid Neutropenia Cyclophosphamide Prednisone Diphenylhydantoin 

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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Robert H. Rubin
    • 1
    • 2
  • Reginald Greene
    • 3
    • 4
  1. 1.Infectious Disease and Transplantation Units, Massachusetts General Hospital, and Department of MedicineHarvard Medical SchoolBostonUSA
  2. 2.Center for Experimental Pharmacology and TherapeuticsHarvard-MIT Division of Health Sciences and TechnologyCambridgeUSA
  3. 3.Chest Division, Radiology Service, Massachusetts General HospitalHarvard Medical SchoolBostonUSA
  4. 4.Department of RadiologyHarvard Medical SchoolBostonUSA

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