Clinical Experience with UFT in Japan

  • Minoru Kurihara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 339)


UFT is an anticancer drug combining Tegafur and uracil in a molar ratio of 1 to 4. Tegafur is absorbed well not only by oral route but also by intrarectal administration, then the Tegafur is gradually converted to 5-FU mainly in the liver microsomes 1 in vivo, and certain level of 5-FU in blood is maintained for a longer period. Furthermore, the incidence of side effects with Tegafur is very low, therefore it can be administered for long period, and from such reasons it has been widely used in clinical practice.


Gastric Cancer Median Survival Period Generalize Wilcoxon Test Intrarectal Administration Lesion Subtype 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Minoru Kurihara
    • 1
  1. 1.Department of Internal MedicineToyosu Hospital, Showa UniversityTokyoJapan

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