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Modulation of the Exocytotic Release of Neurotransmitter Glutamate by Protein Kinase C

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Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 341))

Abstract

Most excitatory synapses in the brain use the amino acid glutamate as their transmitter. Glutamate neurotransmission, being so wide spread, is involved in many functions in the Central Nervous System. Thus, there is evidence that an increase in the effectiveness of glutamatergic synapses mediate some forms of synaptic plasticity which participate in processes of memory and learning. On the other hand, glutamate is involved in the brain damage associated with hypoxia, hypoglycaemia, ischaemia, epilepsy and some neurodegenerative diseases.

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Authors and Affiliations

  1. Departamento de Bioquímica, Facultad de Veterinaria, Universidad Complutense, Madrid, 28040, Spain

    J. Sánchez-Prieto, I. Herrero & M. T. Miras-Portugal

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  1. J. Sánchez-Prieto
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  2. I. Herrero
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  1. Instituto de Investigaciones Citologicas, Valencia, Spain

    Santiago Grisolía  & Vicente Felipo  & 

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Sánchez-Prieto, J., Herrero, I., Miras-Portugal, M.T. (1993). Modulation of the Exocytotic Release of Neurotransmitter Glutamate by Protein Kinase C. In: Grisolía, S., Felipo, V. (eds) Cirrhosis, Hyperammonemia, and Hepatic Encephalopathy. Advances in Experimental Medicine and Biology, vol 341. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2484-7_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2484-7_9

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