Sensitivity of NMDA Receptors to Acute and in Utero Ethanol Exposure
Electrophysiological and biochemical studies have shown that N-methyl-d-aspartate (NMDA) receptors are highly sensitive to inhibition by ethanol. However, some laboratories report that very low ethanol concentrations, in the range of 5 mM or less, inhibit NMDA receptor function, while others report that the confines of ethanol sensitivity may start at somewhat higher concentrations. The review that follows addresses the question of where the literature now stands on the issue of the sensitivity of the NMDA receptor to ethanol.
KeywordsNMDA Receptor Cerebellar Granule Cell Ethanol Exposure Glycine Site NMDA Receptor Function
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