Effect of Acute and Chronic Administration of Ethanol on c-fos Expression in Brain

  • Fei Le
  • Peter Wilce
  • David Hume
  • Brian Shanley


Trans-synaptic activation of neurons occurs over a time frame ranging from milliseconds to hours. Recently, it has been shown that the slower long-term responses, which are thought to underlie neuronal plasticity, are associated with induction of gene expression. The genes involved fall into two major groups: the cellular immediate early genes (IEGs), where transcription is activated rapidly and transiently within minutes of stimulation (Greenberg et al, 1985; Morgan and Curran, 1986) and the late response genes, where expression is induced more slowly over a period of hours (Merlie et al., 1984; Castelluci et al., 1988).


NMDA Receptor GABAA Receptor Kainic Acid Ethanol Vapour Ethanol Withdrawal 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Fei Le
    • 1
  • Peter Wilce
    • 1
  • David Hume
    • 1
  • Brian Shanley
    • 1
  1. 1.Alcohol Research Unit Department of BiochemistryUniversity of QueenslandAustralia

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