Abstract
Much of the pathology caused by alcoholism can be attributed to the continued use of large quantities of ethanol. Alcoholics can expose themselves to extraordinarily large concentrations of ethanol due to an acquired resistance to the drug, termed tolerance. Resistance to ethanol can occur as dispositional (pharmacokinetic) or functional (pharmacodynamic) tolerance (Jaffe, 1985). Dispositional tolerance refers to an alteration in the rate of metabolism, absorption, distribution, or secretion. Functional tolerance refers to adaptive changes that occur within the central nervous system upon chronic ethanol exposure.
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Miles, M.F., Gayer, G., Sganga, M. (1993). Regulation of Neuronal Gene Transcription by Ethanol. In: Alling, C., Diamond, I., Leslie, S.W., Sun, G.Y., Wood, W.G. (eds) Alcohol, Cell Membranes, and Signal Transduction in Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2470-0_26
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DOI: https://doi.org/10.1007/978-1-4615-2470-0_26
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