The Muscarinic Receptor-Stimulated Phosphoinositide Metabolism as a Potential Target for the Neurotoxicity of Ethanol During Brain Development
The underlying molecular events by which EtOH induces its profound deleterious effects on the developing central nervous system (CNS) are still poorly understood. In the past, the accepted scientific view of the effect of EtOH was that it altered neuronal activity by virtue of a non specific interaction with neuronal membranes. However, recent developments suggest that its action may be directed toward pre- and/or post-synaptic events, including synthesis, turnover, release, binding of neurotransmitters to receptor sites, and second messenger systems. In the present chapter, we present data showing a selective interaction of EtOH with muscarinic receptor-stimulated phosphoinositide hydrolysis during postnatal development in the rat suggesting, therefore, that this system may represent a specific and relevant target for the developmental neurotoxicity of EtOH.
KeywordsBrain Development Muscarinic Receptor Fetal Alcohol Syndrome Postnatal Development Muscarinic Agonist
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