Ethanol and Phospholipid Dependent Signal Transduction: The View from the Liver
Receptor-mediated signal transduction processes are common targets of acute or chronic ethanol treatment, both in brain and in peripheral tissues (reviewed in Hoffman and Tabakoff, 1990; Hoek et al, 1992). G protein-linked receptors coupled to adenylate cyclase were studied by several groups in different brain membrane preparations (Hoffman and Tabakoff, 1990). These studies identified the receptor-activated Gs protein α subunit as a likely target of acute ethanol actions in the central nervous system. The sensitivity to ethanol varied both with the receptor and the membrane preparation. Chronic ethanol treatment in vivo decreased the sensitivity to ethanol of adenylate cyclase activation (Hoffman and Tabakoff, 1990). Adenylate cyclase has also been recognized as an indirect target for ethanol in the studies of Diamond and coworkers (1991). Ethanol-induced changes in cellular adenosine uptake affected the extracellular level of this agonist; intracellular responses were determined by the type of adenosine receptors available on specific cells. Long-term ethanol treatment in vitro was associated with a decrease in the expression of the αs subunit for activation of adenylate cyclase (Mochly-Rosen et al, 1988).
KeywordsAdenylate Cyclase Okadaic Acid Ethanol Exposure Signal Transduction System Acute Ethanol
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