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Membrane Cholesterol and Ethanol: Domains, Kinetics, and Protein Function

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Alcohol, Cell Membranes, and Signal Transduction in Brain

Abstract

Approximately 15 years ago, Chin and Goldstein (1977) published a study that was the stimulus for a major effort towards understanding the mechanisms involved in cellular tolerance to ethanol. They had shown that membranes of ethanol-tolerant mice were resistant to the fluidizing effects of ethanol in vitro. This finding has been replicated in several different laboratories using different techniques and different types of membranes (Crews et al., 1983; Harris et al., 1984; Waring et al., 1982; Rottenberg et al., 1981; Ponnappa et al., 1982; Kelly-Murphy et al., 1983; Taraschi et al., 1986; Taraschi et al., 1990; Wood et al., 1989b). Resistance to ethanol-induced fluidization has also been reported in erythrocyte membranes of alcoholics patients (Beauge et al., 1985; Wood et al., 1987).

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Authors and Affiliations

  1. Geriatric Research, Education and Clinical Center VA Medical Center, and Department of Pharmacology, University of Minnesota School of Medicine, Minneapolis, Minnesota, 55417, USA

    W. Gibson Wood, A. Muralikrishna Rao & Urule Igbavboa

  2. Department of Pharmacology and Cell Biophysics, University of Cincinnati, Cincinnati, OH, 45267-004, USA

    Friedhelm Schroeder

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  1. W. Gibson Wood
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  2. A. Muralikrishna Rao
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  3. Friedhelm Schroeder
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Editors and Affiliations

  1. University of Lund, Lund, Sweden

    Christer Alling

  2. The Ernest Gallo Clinic and Research Center, University of California, San Francisco, California, USA

    Ivan Diamond

  3. The University of Texas at Austin, Austin, Texas, USA

    Steven W. Leslie

  4. University of Missouri, Columbia, Missouri, USA

    Grace Y. Sun

  5. Veterans Affairs Medical Center, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA

    W. Gibson Wood

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Wood, W.G., Rao, A.M., Schroeder, F., Igbavboa, U. (1993). Membrane Cholesterol and Ethanol: Domains, Kinetics, and Protein Function. In: Alling, C., Diamond, I., Leslie, S.W., Sun, G.Y., Wood, W.G. (eds) Alcohol, Cell Membranes, and Signal Transduction in Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2470-0_2

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