Mechanisms that Mediate Ethanol-Induced Increases in Dihydropyridine-Sensitive Calcium Channels

  • Robert O. Messing


Chronic alcoholics can develop a hyperexcitable withdrawal syndrome when they abruptly discontinue drinking ethanol. Features of this syndrome include tremor, confusional states, convulsions, delirium, and autonomic dysfunction (Charness et al., 1989). Some manifestations of alcohol withdrawal may result from ethanol-induced changes in the function of voltage-dependent calcium channels, since treatment of rodents made dependent on alcohol with calcium channel antagonists reduces tremors, seizures and mortality during alcohol depravation (Bone et al., 1989, Little et al., 1986, Littleton et al., 1990).


PC12 Cell Calcium Channel Antagonist Ethanol Exposure Ethanol Withdrawal Chronic Ethanol Exposure 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Robert O. Messing
    • 1
  1. 1.Gallo Clinic & Research Center Department of NeurologyUniversity of CaliforniaSan FranciscoUSA

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