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Mechanisms that Mediate Ethanol-Induced Increases in Dihydropyridine-Sensitive Calcium Channels

  • Robert O. Messing

Abstract

Chronic alcoholics can develop a hyperexcitable withdrawal syndrome when they abruptly discontinue drinking ethanol. Features of this syndrome include tremor, confusional states, convulsions, delirium, and autonomic dysfunction (Charness et al., 1989). Some manifestations of alcohol withdrawal may result from ethanol-induced changes in the function of voltage-dependent calcium channels, since treatment of rodents made dependent on alcohol with calcium channel antagonists reduces tremors, seizures and mortality during alcohol depravation (Bone et al., 1989, Little et al., 1986, Littleton et al., 1990).

Keywords

PC12 Cell Calcium Channel Antagonist Ethanol Exposure Ethanol Withdrawal Chronic Ethanol Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bacher, N., Zisman, Y., Berent, E. and Livneh, E., 1991, Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart, Mol Cell Biol. 11: 126.PubMedGoogle Scholar
  2. 2.
    Bell, R.M. and Burns, D.J., 1991, Lipid activation of protein kinase C, J Biol Chem. 266: 4661.PubMedGoogle Scholar
  3. 3.
    Bone, G.H., Majchrowicz, E., Martin, P.R., Linnoila, M. and Nutt, DJ., 1989, A comparison of calcium antagonists and diazepam in reducing ethanol withdrawal tremors, Psychopharmacology. 99: 386.PubMedCrossRefGoogle Scholar
  4. 4.
    Charness, M.E., Simon, R.P. and Greenberg, D.A., 1989, Ethanol and the nervous system, N Engl J Med. 321: 442.PubMedCrossRefGoogle Scholar
  5. 5.
    Dolin, S., Little, H., Hudspith, M., Pagonis, C. and Littleton, J., 1987, Increased dihydropyridine-sensitive calcium channels in rat brain may underlie ethanol physical dependence, Neuropharmacology. 26: 275.PubMedCrossRefGoogle Scholar
  6. 6.
    Gray, R. and Johnston, D., 1987, Noradrenaline and B-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurons, Nature 327: 620.PubMedCrossRefGoogle Scholar
  7. 7.
    Heasley, L.E. and Johnson, G.L., 1989, Regulation of protein kinase C by nerve growth factor, epidermal growth factor, and phorbol esters in PC12 pheochromocytoma cells, J Biol Chem. 264: 8646.PubMedGoogle Scholar
  8. 8.
    Little, H.J., Dolin, S.J. and Halsey, M.J., 1986, Calcium channel antagonists decrease the ethanol withdrawal syndrome, Life Sci. 39: 2059.PubMedCrossRefGoogle Scholar
  9. 9.
    Littleton, J.M., Little, H.J. and Whittington, M.A., 1990, Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644, Psychopharmacology. 100: 387.PubMedCrossRefGoogle Scholar
  10. 10.
    Marks, S.S., Watson, D.L., Carpenter, C.L., Messing, R.O. and Greenberg, D.A., 1989, Comparative effects of chronic exposure to ethanol and calcium channel antagonists on calcium channel antagonist receptors in cultured neural (PC12) cells, J Neurochem. 53: 168.PubMedCrossRefGoogle Scholar
  11. 11.
    Messing, R.O., Carpenter, C.L. and Greenberg, D.A., 1986, Ethanol regulates calcium channels in clonal neural cells, Proc Natl Acad Sci USA. 83: 6213.PubMedCrossRefGoogle Scholar
  12. 12.
    Messing, R.O., Petersen, PJ. and Henrich, C.J., 1991, Chronic ethanol exposure increases levels of protein kinase C δ and ε and protein kinase C-mediated phosphorylation in cultured neural cells, J Biol Chem. 266: 23428.PubMedGoogle Scholar
  13. 13.
    Messing, R.O., Sneade, A.B. and Savidge, B., 1990, Protein kinase C participates in up-regulation of dihydropyridine-sensitive calcium channels by ethanol, J Neurochem. 55: 1383.PubMedCrossRefGoogle Scholar
  14. 14.
    Navarro, J., 1987, Modulation of [3H]dihydropyridine receptors by activation of protein kinase C in chick muscle cells, J Biol Chem. 262: 4649.PubMedGoogle Scholar
  15. 15.
    Nishizuka, Y., 1986, Studies and perspectives of protein kinase C, Science. 233: 305.PubMedCrossRefGoogle Scholar
  16. 16.
    Obeid, L.M., Okazaki, T., Karolak, L.A. and Hannun, Y.A., 1990, Transcriptional regulation of protein kinase C by 1,25-dihydroxyvitamin D3 in HL-60 cells, J Biol Chem. 265: 2370.PubMedGoogle Scholar
  17. 17.
    Rabe, C.S. and Weight, F.F., 1988, Effects of ethanol on neurotransmitter release and intracellular free calcium in PC12 cells, J Pharmacol Exp Ther. 244: 417.PubMedGoogle Scholar
  18. 18.
    Rabin, R.A., 1990, Chronic ethanol exposure of PC 12 cells alters adenylate cyclase activity and intracellular cyclic AMP content, J Pharmacol Exp Ther. 252: 1021.PubMedGoogle Scholar
  19. 19.
    Reuter, H., Kokubun, S. and Prod’hom, B., 1986, Properties and modulation of cardiac calcium channels, J Exp Biol. 124: 191.PubMedGoogle Scholar
  20. 20.
    Skattebol, A. and Rabin, R., 1987, Effects of ethanol on 45Ca2+ uptake in synaptosomes and in PC12 cells, Biochem Pharmacol. 36: 2227.PubMedCrossRefGoogle Scholar
  21. 21.
    Strong, J.A., Fox, A.P., Tsien, R.W. and Kaczmarek, L.K., 1987, Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons, Nature. 325: 714.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Robert O. Messing
    • 1
  1. 1.Gallo Clinic & Research Center Department of NeurologyUniversity of CaliforniaSan FranciscoUSA

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