Abstract
Chronic alcoholics can develop a hyperexcitable withdrawal syndrome when they abruptly discontinue drinking ethanol. Features of this syndrome include tremor, confusional states, convulsions, delirium, and autonomic dysfunction (Charness et al., 1989). Some manifestations of alcohol withdrawal may result from ethanol-induced changes in the function of voltage-dependent calcium channels, since treatment of rodents made dependent on alcohol with calcium channel antagonists reduces tremors, seizures and mortality during alcohol depravation (Bone et al., 1989, Little et al., 1986, Littleton et al., 1990).
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© 1993 Springer Science+Business Media New York
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Messing, R.O. (1993). Mechanisms that Mediate Ethanol-Induced Increases in Dihydropyridine-Sensitive Calcium Channels. In: Alling, C., Diamond, I., Leslie, S.W., Sun, G.Y., Wood, W.G. (eds) Alcohol, Cell Membranes, and Signal Transduction in Brain. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2470-0_15
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DOI: https://doi.org/10.1007/978-1-4615-2470-0_15
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