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Actions of Alcohols and other Sedative/Hypnotic Compounds on Cation Channels Associated with Glutamate and 5-HT3 Receptors

  • David M. Lovinger
  • Robert W. Peoples

Abstract

The neural actions of a number of sedative/hypnotic agents appear to be mediated via alterations in the function of neurotransmitter receptors of the ligand-gated ion channel class. For example, it has long been known that barbiturates and benzodiazepines potentiate responses mediated by GABAA receptors (Schmidt, 1963; Nicoll, 1972; Ransom and Barker, 1976; Choi et al., 1981; Study and Barker, 1981; Olsen, 1982; Gage and Robertson, 1985; Vicini et al., 1987) and that this action likely underlies the sedative and anesthetic actions of these compounds. Ethanol (EtOH) also has potent actions on a number of different ligand-gated channels. Intoxicating concentrations of ethanol have been shown to inhibit responses mediated by the NMDA-type glutamate receptor (Dildy and Leslie, 1989; Hoffman et al., 1989; Lima-Landman and Albuquerque, 1989; Lovinger et al., 1989; Göthert and Fink, 1989), while ethanol is less potent in inhibiting AMPA/kainate receptor-mediated responses (Hoffman et al, 1989; Lovinger et al., 1989; Lovinger et al., 1990). In contrast, ethanol potentiates the function of other ligand-gated ion channels including some types of GABAA receptors (Mehta and Ticku, 1988; Suzdak et al., 1986; Nakahiro et al., 1991; Wafford et al., 1990), 5-HT3 receptors (Lovinger, 1991), strychnine-sensitive glycine receptors (Celentano et al., 1988) and nicotinic acetylcholine receptors (Okada, 1967; Miller et al., 1991).

Keywords

NMDA Receptor Glutamate Receptor GABAA Receptor Discriminative Stimulus Effect Ethanol Sensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • David M. Lovinger
    • 1
  • Robert W. Peoples
    • 2
  1. 1.Department of Molecular Physiology and BiophysicsVanderbilt University Medical SchoolNashvilleUSA
  2. 2.Laboratory of Molecular Physiology and PharmacologyNational Institute on Alcohol Abuse and AlcoholismRockvilleUSA

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