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In Vivo Studies of Ethanol Interactions with N-Methyl-D-Aspartate Systems in Rat Brain

  • Lynn C. Roper
  • Rueben A. Gonzales

Abstract

Several electrophysiological and biochemical studies have indicated that N-methyl-D-aspartate (NMDA) receptor functions may be altered by ethanol (Gonzales, 1990). Many have suggested that ethanol potently and selectively inhibits the actions of agonists at the NMDA receptor (Hoffman et al., 1989; Lovinger et al., 1989; Gothert and Fink, 1989; Hoffman et al., 1990; Woodward and Gonzales, 1990). Others have implicated the involvement of the NMDA receptor in acute behavioral effects of ethanol such as memory dysfunction (Hoffman et al., 1990) and in certain aspects of ethanol withdrawal symptoms, such as seizures (Grant et al., 1990).

Keywords

NMDA Receptor Striatal Slice Ethanol Inhibition Striatal Synaptosome Competitive NMDA Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Lynn C. Roper
    • 1
  • Rueben A. Gonzales
    • 1
  1. 1.Department of PharmacologyUniversity of TexasAustinUSA

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