In Vivo Studies of Ethanol Interactions with N-Methyl-D-Aspartate Systems in Rat Brain
Several electrophysiological and biochemical studies have indicated that N-methyl-D-aspartate (NMDA) receptor functions may be altered by ethanol (Gonzales, 1990). Many have suggested that ethanol potently and selectively inhibits the actions of agonists at the NMDA receptor (Hoffman et al., 1989; Lovinger et al., 1989; Gothert and Fink, 1989; Hoffman et al., 1990; Woodward and Gonzales, 1990). Others have implicated the involvement of the NMDA receptor in acute behavioral effects of ethanol such as memory dysfunction (Hoffman et al., 1990) and in certain aspects of ethanol withdrawal symptoms, such as seizures (Grant et al., 1990).
KeywordsNMDA Receptor Striatal Slice Ethanol Inhibition Striatal Synaptosome Competitive NMDA Antagonist
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