Use of the Hypertensive Agent Angiotensin Ii for Modifying Oxygen Delivery to Tumours

  • Gillian M. Tozer
  • Katija M. Shaffi
  • David G. Hirst
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 345)


Ischaemia-induced tumour hypoxia can limit the effectiveness of radiotherapy. Regions of deficient blood flow within tumours also limit the access of blood-borne anti-cancer agents. Vasoconstrictor drugs, such as angiotensin II, have potential for improving the oxygen status of tumours via an increase in their blood flow. This would occur if the tumour perfusion pressure could be increased without increasing tumour vascular resistance. An increase in absolute tumour blood flow following i.v. infusion of angiotensin II has been reported in the literature (Hori et al.,1991,Tanda et al.,1991,Tokuda et al.,1990).The aims of this study were 1) to determine the relationship between blood flow response to angiotensin II and perfusion pressure and 2) to investigate whether angiotensin II induces any improvement in blood flow to very poorly perfused tumour regions which are critical for the outcome of both radiotherapy and chemotherapy.


Blood Flow Perfusion Pressure Mean Arterial Blood Pressure Interstitial Fluid Pressure Tumour Blood Flow 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Gillian M. Tozer
    • 1
  • Katija M. Shaffi
    • 1
  • David G. Hirst
    • 1
  1. 1.CRC Gray LaboratoryMount Vernon HospitalNorthwood MiddlesexEngland

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