Abstract
Ischaemia-induced tumour hypoxia can limit the effectiveness of radiotherapy. Regions of deficient blood flow within tumours also limit the access of blood-borne anti-cancer agents. Vasoconstrictor drugs, such as angiotensin II, have potential for improving the oxygen status of tumours via an increase in their blood flow. This would occur if the tumour perfusion pressure could be increased without increasing tumour vascular resistance. An increase in absolute tumour blood flow following i.v. infusion of angiotensin II has been reported in the literature (Hori et al.,1991,Tanda et al.,1991,Tokuda et al.,1990).The aims of this study were 1) to determine the relationship between blood flow response to angiotensin II and perfusion pressure and 2) to investigate whether angiotensin II induces any improvement in blood flow to very poorly perfused tumour regions which are critical for the outcome of both radiotherapy and chemotherapy.
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References
Anderson, J.H., Willmott, N., Bessent, R., Angerson, WJ., Kerr, D.J. & McArdle, C.S., 1991, Regional chemotherapy for inoperable renal carcinoma: a method of targeting therapeutic microspheres to tumour, Br. J. Cancer 64:365.
Brown, J. M. Exploitation of bioreductive agents with vasoactive drugs, in: “Proc. 8th International Congress of Radiation Research, Edinburgh, U.K., 1987” Taylor & Francis, London. Vol. 2, p 719.
Boucher, Y., Baxter, L.T. & Jain, R.K., 1990, Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy, Cancer Research 50:4478.
Hirst D. G, Hirst, V.K., Shaffi, K.M., Prise, V.E. & Joiner, B., 1991, The influence of vasoactive agents on the perfusion of tumours growing in three sites in the mouse, Int. J. Radial. Biol. 60:211.
Hirst, D.G. & Tozer, G.M., 1992, Pharmacological manipulation of blood flow, Br. J. Radiol., in press
Hori, K., Suzuki, M., Tanda, S., Saito, S., Shinozaki, M. & Zhang, Q.H., 1991, Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension, Jpn. J. Cancer Res.82:0..
Jirtle, R., Clifton, K.H. & Rankin, J.H.G., 1978, Effects of several vasoactive drugs on the vascular resistance of MT-W9B tumors in W/Fu rats, Cancer Res. 38:2385.
Kety, S.S., 1960, Theory of blood tissue exchange and its application to measurements of blood flow, Methods Med. Res. 8:223.
Kobayashi, H., Hasuda, K., Aoki, K., Taniguchi, S. & Baba, T., 1990, Systemic chemotherapy in tumour-bearing rats using high-dose cis-diamminedichloroplatinum (ii) with low nephrotoxicity in combination with angiotensin II and sodium thiosulfate,Int. J. Cancer 45:940.
Kobayashi, H., Hasuda, K., Taniguchi, S. & Baba, T., 1991, Therapeutic efficacy of two-route chemotherapy using cis-diamminedichloroplatinum (II) and its antidote, sodium thiosulfate, combined with the angiotensin-Il-induced hypertension method in a rat uterine tumor, Int. J. Cancer 47:893.
Less, J.R., Possner, M.C., Boucher, Y., Wolmark, N. & Jain, R.K., 1991, Elevated interstitial fluid pressure in human tumors, Pro. Am. Assoc. Cancer Res. 32:59.
Noguchi, S., Miyachi,K., Nishizawa, Y., Sasaki, Y., Imaoka, S., Iwanaga, T., Koyama, H. and Terasawa, T., 1988, Augmentation of anti-cancer effect with angiotensin II in intra-arterial infusion chemotherapy for breast carcinoma, Cancer 62:467.
Sasaki, Y., Imaoka, S., Hasegawa, Y., Nakano, S., Ishikawa, O., Ohigashi, H., Taniguchi, K., Koyama, H., Iwanaga, T. and Terasawa, T., 1985, Changes in distribution of hepatic blood flow induced by intraarterial infusion of angiotensin II in human hepatic cancer, Cancer 55:311.
Takematsu, H., Tomita, Y. & Kato, T., 1985, Angiotensin-induced hypertension and chemotherapy for multiple lesions of malignant melanoma, Brit. J. Dermatol. 113:463.
Tanda, S., Hori, K., Saito, S., Shinozaki, M., Zhang, Q.H. & Suzuki, M., 1991, Comparison of the effects of intravenously bolus-administered endothelin-1 and infused angiotensin II on the subcutaneous tumor blood flow in anaethetized rats, Jpn. J. Cancer Res. 82:958.
Tokuda, K., Abe, H., Aida, T., Sugimoto, S. & Kaneko, S., 1990, Modification of tumor blood flow and enhancement of therapeutic effect of ACNU on experimental rat gliomas with angiotensin II, J. Neurooncol. 8:205.
Tozer, G.M., Lewis, S., Michalowski, A. & Aber, V., 1990, The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma, Br. J. Cancer 61:250.
Tozer, G.M. & Shaffi, K. M., 1992, Modification of tumour blood flow using the hypertensive agent, angiotensin II, Submitted to Br. J. Cancer.
Wiig, H., Tveit, E., Hultborn, R., Reed, R.K. and Weiss, L., 1982, Interstitial fluid pressure in DMBAinduced rat mammary tumours, Scand. J. Clin. Lab. Invest. 42:159.
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Tozer, G.M., Shaffi, K.M., Hirst, D.G. (1994). Use of the Hypertensive Agent Angiotensin Ii for Modifying Oxygen Delivery to Tumours. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_56
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_56
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