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Phagocytosis of Colloidal Carbon After Administration of Perfluorochemicals of First and Second Generation

  • Chapter
Oxygen Transport to Tissue XV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 345))

Abstract

Artificial oxygen carriers of the perfluorochemical type are marked by their high capacity for carrying dissolved oxygen1–3. After circulating in the blood stream they are removed from the circulation and stored for a certain time period chiefly by cells of the reticulo-endothelial system (RES).4–7 To indirectly assess the duration of this storage, the elimination of colloidal carbon particles from the blood stream can be used as an indicator of the residual phagocytic activity of these cells.4,8–10

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References

  1. Geyer RP (1975): Review of perfluorochemical-type blood substitutes. Proceedings of the Xth Int. Congress for Nutrition, Kyoto 1975, 3–19

    Google Scholar 

  2. Riess JG, Le Blanc M (1982): Solubility and transport phenomena in perfluorochemicals relevant to blood substitution and other biomedical applications. Pure & Appl. Chem. 54, 2383–2406

    CAS  Google Scholar 

  3. Long DM, Long DC, Mattrey RF, Long RA, Burgan AR, Herrick WC, Shellhamer DF (1988): An overview of perfluoroctylbromide - application as a synthetic oxygen carrier and imaging agent for x-ray, ultrasound and nuclear magnetic resonance. Biomat. Art. Cells Art. Organs 16, 411–420

    CAS  Google Scholar 

  4. Lutz J, Metzenauer P (1980): Effects of potential blood substitutes (perfluorochemicals) on rat liver and spleen. Pflueg. Arch. (Europ. J. Physiol.) 387, 175–181

    Article  CAS  Google Scholar 

  5. Fujita T, Suzuki C, Ogawa R (1983): Effect of Fluosol-DA on the reticulo-endothelial system function in surgical patients. Prog. Clin. Biol. Res. 122, 265–272

    PubMed  CAS  Google Scholar 

  6. Castro O, Nesbitt E, Lyles D (1984): Effect of a perfluorocarbon emulsion (Fluosol-DA) on reticuloendothelial system clearance function. Am. J. Hematol 16, 15–21

    Article  PubMed  CAS  Google Scholar 

  7. Lutz J (1985): Effect of perfluorochemicals on host defense, especially on the reticuloendothelial system. Int. Anesthesiol. Clinics 23, 63–93

    Article  CAS  Google Scholar 

  8. Biozzi G, Benacerraf B, Halpern BN (1953): Quantitative study of the granulopectic activity of the reticulo-endothelial system. Br. J. Pathol. 34, 441–457

    CAS  Google Scholar 

  9. Biozzi G, Stiffel C (1965): The physiopathology of the reticulo-endothelial cells of the liver and spleen. In: Progress in Liver Diseases Vol.2. (Eds. Poper H, Schaffner F) Grune & Stratton, New York, p.166–191

    Google Scholar 

  10. Altura BM (1974): Hemorrhagic shock and reticuloendothelial system phagocytic function in pathogen-free animals. Circ. Shock 1, 295–300

    Google Scholar 

  11. Naito R, Yokoyama K (1978): Perfluorochemical blood substitutes Fluosol-43, Fluosol-DA 20% and 35%. Technical Information No 5, Green Cross Corp., Osaka, 1–177

    Google Scholar 

  12. Yokoyama K, Yamanouchi K, Ohyanagi H, Mitsuno T (1978): Fate of perfluorochemicals in animals after intravenous injection or hemodilution with their emulsions. Chem. Pharm. Bull. 26, 956–966

    Article  PubMed  CAS  Google Scholar 

  13. Naito R (1980): Synthetic blood, what is it? And what will be its effect on the blood/plasma system? Plasma Forum/Amer. Blood Resources Ass. 1980, 154–171

    Google Scholar 

  14. Faithfull NS (1992): Oxygen delivery from fluorocarbon emulsions - aspects of convective and diffusive transport. Biomat. Art. Cells Immob. Biotech. 20, 797–804

    CAS  Google Scholar 

  15. Flaim SF, Hazard DR, Hogan J, Peters RM (1991): Characterization and mechanism of side-effects of oxygentTM HT (highly concentrated fluorocarbon emulsion) in swine. Biomat. Art. Cells Immob Biotech. 19, 383

    Google Scholar 

  16. Meyer KL, Carvlin MJ, Mukherji B, Sloviter H, Joseph PM (1992): Fluorinated blood substitute retention in the rat measured by fluorine-19 magnetic resonance imaging. Investig. Radiology 8, 620–627

    Google Scholar 

  17. Lutz J, Stark M (1987): Half life and changes in the composition of a perfluorochemical emulsion within the vascular system of rats. Europ. J. Physiol. 410, 181–184

    CAS  Google Scholar 

  18. Gehr P, Brain JD, Bloom SB, Valberg PA (1983): Magnetic particles in the liver: a probe for intracellular movement. Nature 302, 336–338

    Article  PubMed  CAS  Google Scholar 

  19. Gehr P, Brain JD, Bloom SB (1984): Noninvasive studies of Kupffer cells in situ by magnetometry. J. Leukocyte Biol. 35, 19–30

    PubMed  CAS  Google Scholar 

  20. Weinstock SB, Brain JD (1988): Comparison of particle clearance and macrophage phagosomal motion in liver and lungs of rats. J. Appl. Physiol. 65, 1811–1820

    PubMed  CAS  Google Scholar 

  21. Lutz J, Augustin AJ, Schwegler JS, Milz J (1992): Magnetometric studies on the reticuloendothelial system of the liver after administration of different lipid emulsions. Life Sciences 50, 1503–1510

    Article  PubMed  CAS  Google Scholar 

  22. Koester MB, Lutz J (1993) Magnetometric measurements of macrophage activity in the liver after administration of artificial oxygen carriers. Advances in Exp. Med. & Biol. (This volume, in press)

    Google Scholar 

  23. Lutz J, Barthel U, Metzenauer P (1982): Variation in toxicity of Escherichia coli endotoxin after treatment with pertluorinated blood substitutes in mice. Circ. Shock 9, 99–106

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Physiologisches Institut der Universitaet Wuerzburg, Roentgenring 9, D-W 8700, Wuerzburg, Germany

    L. J. E. Jäger & J. Lutz

Authors
  1. L. J. E. Jäger
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  2. J. Lutz
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Editors and Affiliations

  1. Johannes Gutenberg-Universität, Mainz, Germany

    Peter Vaupel  & Rolf Zander  & 

  2. University of Maryland Baltimore County, Baltimore, Maryland, USA

    Duane F. Bruley

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© 1994 Springer Science+Business Media New York

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Jäger, L.J.E., Lutz, J. (1994). Phagocytosis of Colloidal Carbon After Administration of Perfluorochemicals of First and Second Generation. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_29

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  • DOI: https://doi.org/10.1007/978-1-4615-2468-7_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6051-3

  • Online ISBN: 978-1-4615-2468-7

  • eBook Packages: Springer Book Archive

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