Abstract
Perfluorochemical (PFC) liquids are inert compounds with high solubility for all gases. Physiological oxygen and carbon dioxide transport was first demonstrated in 1966 by the survival of mice subjected to liquid breathing by being completely submerged in an oxygenated liquid PFC.1 PFCs are insoluble in water, and for the past 25 years significant efforts have been directed towards the development of biocompatible PFC emulsions for use as intravenous oxygen carriers.2 The first product developed was Fluosol ® (Green Cross Corp., Japan),3 which was recently approved by the FDA for use as an oxygen carrier in high-risk patients undergoing percutaneous transluminal coronary balloon angioplasty (PTCA) procedures.4 Major disadvantages of Fluosol include its low concentration of PFC (20% w/v) and the necessity for frozen storage (due to the inherent instability of the emulsion).
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References
L.C. Clark and R. Gollan, Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure, Science 152:179 (1966).
R.P. Geyer, PFC as blood substitutes - An overview, in: “Advances In Blood Substitute Research,” R.B. Bolin, R.P. Geyer, G.J. Nemo, eds., Alan R. Liss, New York: 157 (1983).
R. Naito and K. Yokoyama, “Perfluorochemical Blood Substitutes,” Technical Information Series No. 5., Green Cross Corp, Osaka, Japan (1978).
Fluosol ®. Summary Basis of Approval, Reference number OB-NDA 86–0909. December 26, 1989.
J.G. Riess, Fluorocarbon-based in vivo oxygen transport and delivery systems, Vox Sanguinis 61:225 (1991).
P.E. Keipert, N.S. Faithfull, R.M. Peters, Enhancement of oxygen delivery by a perfluorochemical emulsion following acute hemodilution in dogs, FASEB J. 6:A1350 (1992).
L. Stehling and H.L. Zander, Acute normovolemic hemodilution, Transfusion 31:857 (1991).
G.R. Kelman, Digital computer subroutine for the conversion of oxygen tension into saturation, J. Appl. Physiol. 21:1375 (1966).
T.F. Zuck and P.M. Carey, Autologous transfusion practice, Vox Sanguinis 58:234 (1990).
N.S. Faithfull, Oxygen delivery from fluorocarbon emulsions - aspects of convective and diffusive transport, Bioniat.,Artif Cells, Intmob. Biotech. 20: 797 (1992).
J.A. Kaplan, Hemodynamic Monitoring, in: “Cardiac Anesthesia”, J.A. Kaplan. ed, Grune and Stratton, New York, San Francisco, London (1979).
S.M. Cain, Oxygen delivery and uptake in dogs during anemic and hypoxie hypoxia, J. Appl. Physiol. 42:228 (1979).
G.P. Biro, M. Masika, B. Korecky, Oxygen delivery and performance in the. isolated, perfused rat heart: comparison of perfusion with aqueous and perfluorocarbon-containing media. Adv. Exp. Biol. Med. 248:509 (1989).
P.E. Keipert, Properties of chemically crosslinked hemoglobin solutions designed as temporary oxygen carriers. in: “Oxygen Transport to Tissues XIV”, W. Erdmann, D.F. Bruley, eds., Plenum Press, New York: 453 (1992).
G. Lenz, H. Junger, R. van den Ende, B. Brotman, A.M. Prince, Hemodynamic effects after partial exchange transfusion with pyridoxylated polyhemoglobin in chimpanzees, Bionuu. Arty: Cells Inunob. Biotech. 19:709 (1991).
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© 1994 Springer Science+Business Media New York
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Keipert, P.E. et al. (1994). Oxygen Delivery Augmentation by Low-Dose Perfluorochemical Emulsion During Profound Normovolemic Hemodilution. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_26
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_26
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