Abstract
Since tobacco smoke contains 1.5–4.5% carbon monoxide cigarette smoking induces a rise in the blood CO-hemoglobin concentration with a subsequent decrease in the O2-capacity and a simultaneous increase in the hemoglobin O2-affinity. Both effects cause a restriction of respiratory gas exchange. Aim of the present study was to investigate the influence of tobacco smoking during pregnancy on the O2-affinity and the CO2-binding of maternal blood. Using the derived results, a model describing the blood O2 dissociation curve for the conditions of increased concentrations of CO-hemoglobin and of 2,3-DPG was developed. In addition, maternal to fetal oxygen transfer at elevated CO-hemoglobin fractions in maternal blood was analysed.
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© 1994 Springer Science+Business Media New York
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Grote, J., Dall, P., Oltmanns, K., Stolp, W. (1994). The Effect of Increased Blood Carbon Monoxide Levels on the Hemoglobin Oxygen Affinity During Pregnancy. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_19
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_19
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