Abstract
After peripheral chemodenervation, hypoxia is generally expected to cause ventilatory depression, but also tachypnea has been observed1. The latter response appeared to depend on the integrity of the vagus nerves2. Furthermore, according to the “Reaction Theory”3, hypoxia-induced systemic lactic acidosis should increase pulmonary ventilation via central chemosensitivity, provided the extracellular fluid (ECF) pH in the brainstem is thereby reduced. However, hypoxia-induced systemic lactic acidosis failed to stimulate ventilation in peripherally chemodenervated cats in spite of a pronounced fall in ECF-pH4.
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© 1994 Springer Science+Business Media New York
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Kiwull-Schöne, H., Kiwull, P., Kalhoff, H. (1994). Pulmonary Vagal Afferents Versus Central Chemosensitivity in the Ventilatory Response to Hypoxia and Lactic Acidosis. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_16
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_16
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