Effects of 5-Hydroxytryptamine Inhibition on Gas Exchange and Pulmonary Hemodynamics in Acute Canine Pulmonary Embolism

  • A. Kawai
  • A. Umeda
  • M. Mori
  • T. Takasugi
  • K. Yamaguchi
  • T. Kawashiro
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 345)

Abstract

5-Hydroxytryptamine (Serotonin; 5-HT), a potent vasoconstrictor of pulmonary arteries, has been reported to play an important role in cardiopulmonary dysfunction that accompanies pulmonary embolization (Huval et al.,1983). The quantitative effects of 5-HT on gas exchange efficiency, however, have not been systematically investigated in pulmonary embolism. Using a new type of selective serotonin receptor antagonist, we examined the distribution of ventilation-perfusion (VA/Q) ratios and pulmonary hemodynamics to clarify the effects of serotonin on gas exchange in acute canine pulmonary embolism.

Keywords

Catheter Acetone Attenuation Bromide Polyethylene 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Caldini, P., 1965, Pulmonary hemodynamics and arterial oxygen saturation in pulmonary emboli, J.Appl.Physiol. 20: 184–190.Google Scholar
  2. Cheney, F., Paulin, J., and Ferene, B.S., 1973, Effect of pulmonary microembolism on arteriovenous shunt flow, J.Thorac.Cardiovasc.Surg. 4: 473–477.Google Scholar
  3. Colebatch, H.J.H., Olsen, C.R.,and Nadel, J.A.,1966, Effect of histamine, serotonin and acetylcholine on the peripheral airway, J.Appl.Physiol. 21: 217–226.PubMedGoogle Scholar
  4. Huval, W.V., Mathieson, M.A., Stemp, L.I., Dunham, B.M., Jones, A.G., Shepro, D., and Hechtman, H.B., 1983, Therapeutic benefits of 5-hydroxytyptamine inhibition following pulmonary embolism, Ann.Surg.197:220–225.PubMedCrossRefGoogle Scholar
  5. Hyland, J.W., Piemme T.E., and Alexander S., 1963, Behavior of pulmonary hypertension produced by serotonin and emboli, Am. J. Physiol. 205: 591–597.PubMedGoogle Scholar
  6. Ishibe, Y.,Suekane, K., Nakamura, M., Izumi, T., Umeda, T., Sagawa, Y., Satoh, K., and Oh, M., 1987, Measurement of lung water with double indicator dilution method using heat and sodium ions in dogs, Jap.Anesth.J.Rev. 2:5–7.Google Scholar
  7. Levy S.E., Simmons, D.H., 1971, Serotonin pulmonary hypertension and airway constriction in the anesthetized dog, Pro. Sci. Exp.Biol.Med. 138:365–368.Google Scholar
  8. Morishima, Y., Tanaka, T., Watanabe, K., Igarashi, T., Yasuoka, M., and Shibano, T.,1991, Prevention by DV-7028, a selective 5-HT2 receptor antagonist, of the formation coronary thrombi in dogs, Cardiovasc.Resear. 25: 727–730.CrossRefGoogle Scholar
  9. Thomas, D.P.,and Gurewich, V., 1966, Role of platelets in sudden death induced by experimental pulmonary emboli, Circulation 22: 207–209.Google Scholar
  10. Thomas, D.P., Gurewich, V., and Ashford T.P., 1966, Platelet adherence to thromboembolism, N. Engl. J. Med. 274: 952–958Google Scholar
  11. Thompson, J.A., Millen, J.E., Glauser, F.L., and Hess, M.L., 1986, Role of 5-HT2 receptor inhibition in pulmonary embolism, Circulatory Shock 20:299–309.PubMedGoogle Scholar
  12. Utsonomiya, T., Krausz, M.M., Levine, L., Shepro, D., and Hechtman, H.B., 1982, Thromboxane mediation of cardiopulmonary effects of embolism, J. Clin. Invest. 70:361–368.PubMedCrossRefGoogle Scholar
  13. Wagner, P.D., Saltzman, H.A., and West, J.B., 1974 Measurement of continuous distribution of ventilation-perfusion ratios: Theory, J.Appl.Physiol. 36:588–599.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • A. Kawai
    • 1
  • A. Umeda
    • 1
  • M. Mori
    • 1
  • T. Takasugi
    • 1
  • K. Yamaguchi
    • 1
  • T. Kawashiro
    • 1
  1. 1.Department of MedicineKeio University School of MedicineTokyoJapan

Personalised recommendations