Abstract
5-Hydroxytryptamine (Serotonin; 5-HT), a potent vasoconstrictor of pulmonary arteries, has been reported to play an important role in cardiopulmonary dysfunction that accompanies pulmonary embolization (Huval et al.,1983). The quantitative effects of 5-HT on gas exchange efficiency, however, have not been systematically investigated in pulmonary embolism. Using a new type of selective serotonin receptor antagonist, we examined the distribution of ventilation-perfusion (VA/Q) ratios and pulmonary hemodynamics to clarify the effects of serotonin on gas exchange in acute canine pulmonary embolism.
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References
Caldini, P., 1965, Pulmonary hemodynamics and arterial oxygen saturation in pulmonary emboli, J.Appl.Physiol. 20: 184–190.
Cheney, F., Paulin, J., and Ferene, B.S., 1973, Effect of pulmonary microembolism on arteriovenous shunt flow, J.Thorac.Cardiovasc.Surg. 4: 473–477.
Colebatch, H.J.H., Olsen, C.R.,and Nadel, J.A.,1966, Effect of histamine, serotonin and acetylcholine on the peripheral airway, J.Appl.Physiol. 21: 217–226.
Huval, W.V., Mathieson, M.A., Stemp, L.I., Dunham, B.M., Jones, A.G., Shepro, D., and Hechtman, H.B., 1983, Therapeutic benefits of 5-hydroxytyptamine inhibition following pulmonary embolism, Ann.Surg.197:220–225.
Hyland, J.W., Piemme T.E., and Alexander S., 1963, Behavior of pulmonary hypertension produced by serotonin and emboli, Am. J. Physiol. 205: 591–597.
Ishibe, Y.,Suekane, K., Nakamura, M., Izumi, T., Umeda, T., Sagawa, Y., Satoh, K., and Oh, M., 1987, Measurement of lung water with double indicator dilution method using heat and sodium ions in dogs, Jap.Anesth.J.Rev. 2:5–7.
Levy S.E., Simmons, D.H., 1971, Serotonin pulmonary hypertension and airway constriction in the anesthetized dog, Pro. Sci. Exp.Biol.Med. 138:365–368.
Morishima, Y., Tanaka, T., Watanabe, K., Igarashi, T., Yasuoka, M., and Shibano, T.,1991, Prevention by DV-7028, a selective 5-HT2 receptor antagonist, of the formation coronary thrombi in dogs, Cardiovasc.Resear. 25: 727–730.
Thomas, D.P.,and Gurewich, V., 1966, Role of platelets in sudden death induced by experimental pulmonary emboli, Circulation 22: 207–209.
Thomas, D.P., Gurewich, V., and Ashford T.P., 1966, Platelet adherence to thromboembolism, N. Engl. J. Med. 274: 952–958
Thompson, J.A., Millen, J.E., Glauser, F.L., and Hess, M.L., 1986, Role of 5-HT2 receptor inhibition in pulmonary embolism, Circulatory Shock 20:299–309.
Utsonomiya, T., Krausz, M.M., Levine, L., Shepro, D., and Hechtman, H.B., 1982, Thromboxane mediation of cardiopulmonary effects of embolism, J. Clin. Invest. 70:361–368.
Wagner, P.D., Saltzman, H.A., and West, J.B., 1974 Measurement of continuous distribution of ventilation-perfusion ratios: Theory, J.Appl.Physiol. 36:588–599.
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© 1994 Springer Science+Business Media New York
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Kawai, A., Umeda, A., Mori, M., Takasugi, T., Yamaguchi, K., Kawashiro, T. (1994). Effects of 5-Hydroxytryptamine Inhibition on Gas Exchange and Pulmonary Hemodynamics in Acute Canine Pulmonary Embolism. In: Vaupel, P., Zander, R., Bruley, D.F. (eds) Oxygen Transport to Tissue XV. Advances in Experimental Medicine and Biology, vol 345. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2468-7_10
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DOI: https://doi.org/10.1007/978-1-4615-2468-7_10
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