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The Uvomorulin—Catenin Complex

Insights into the Structure and Function of Cadherins

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Cellular Adhesion

Part of the book series: New Horizons in Therapeutics ((NHTH))

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Abstract

Cadherins are a protein family of Ca2+-dependent transmembrane-type cell adhesion molecules. They mediate Ca2+-dependent cell-cell adhesion by homophilic binding. All solid tissues in vertebrates express some Cadherins. Very importantly for their function, the different Cadherin subtypes show distinct developmental and tissue-specific patterns of expression and display corresponding binding specificities. In this way, Cadherins are thought to influence cell sorting, morphogenesis, and the maintenance of adult tissues (Takeichi, 1988, 1991; Kemler et al., 1989).

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Authors and Affiliations

  1. Division of Molecular Embryology, Max-Planck Institute for Immunobiology, W-7800, Freiburg, Germany

    Martin Ringwald

  2. The Jackson Laboratory, Bar Harbor, Maine, USA, 04609

    Martin Ringwald

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  1. Martin Ringwald
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Editors and Affiliations

  1. SmithKline Beecham Pharmaceuticals, Philadelphia, Pennsylvania, USA

    Brian W. Metcalf , Barbara J. Dalton  & George Poste ,  & 

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Ringwald, M. (1994). The Uvomorulin—Catenin Complex. In: Metcalf, B.W., Dalton, B.J., Poste, G., Schatz, J. (eds) Cellular Adhesion. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2466-3_5

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