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Angiotensin Receptors pp 17–48Cite as

Molecular Biology of Angiotensin II Receptors

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Abstract

Angiotensin II (ANG II), a central component of the renin—angiotensin— aldosterone system, helps to sustain blood pressure by affecting multiple targets.1,2 ANG II stimulates glomerulosa cells of the adrenal cortex to release aldosterone, which is responsible for reabsorption of sodium and water in the kidney, and increases heart rate and contractile force and constricts blood vessel smooth muscle cells, thus increasing blood pressure. In the kidney, ANG II contracts glomerular mesangial cells and smooth muscle in efferent arterioles, resulting in a decrease in filtration. It also stimulates epithelial cells of the proximal tubules and promotes reabsorption of sodium and water. In addition, ANG II increases pituitary secretion of vasopressin, a vasoconstrictor and antidiuretic hormone. In the brain, ANG II induces thirst and salt appetite. Finally, ANG II increases catecholamine release by stimulating central sympathetic activity and secretion by adrenal chromaffin cells.

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Authors and Affiliations

  1. Cardiology Division, Emory University School of Medicine, Atlanta, Georgia, 30322, USA

    Bernard Lassègue, Kathy K. Griendling & R. Wayne Alexander

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  1. Bernard Lassègue
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  2. Kathy K. Griendling
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  3. R. Wayne Alexander
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  1. National Institute of Mental Health National Institutes of Health, Bethesda, Maryland, USA

    Juan M. Saavedra

  2. The DuPont Merck Pharmaceutical Company, Wilmington, Delaware, USA

    Pieter B. M. W. M. Timmermans

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Lassègue, B., Griendling, K.K., Alexander, R.W. (1994). Molecular Biology of Angiotensin II Receptors. In: Saavedra, J.M., Timmermans, P.B.M.W.M. (eds) Angiotensin Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2464-9_2

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