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Angiotensin II Receptor

Molecular Cloning, Functions, and Regulation

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Book cover Angiotensin Receptors

Abstract

The diversity of specific physiological effects elicited by angiotensin II1,2 (ANG II) poses a simple but important question: Are they mediated by a single or multiple type of receptors? While workers on ANG II action expected more than one subtype as suggested by the presence of the dithiothreitolsensitive and -insensitive receptors, exceeding instability of the receptor protein thwarted numerous attempts at obtaining direct evidence for its multiplicity. Thus, the development of the new types of ANG II receptor antagonists,3–5 which turned out to be isoform specific, was the important turning point that provided indirect but important tools to reveal the problem of ANG II receptor properties.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, 37232-0146, USA

    Tadashi Inagami, Masato Mizukoshi & Deng-Fu Guo

Authors
  1. Tadashi Inagami
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  2. Masato Mizukoshi
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  3. Deng-Fu Guo
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Editor information

Editors and Affiliations

  1. National Institute of Mental Health National Institutes of Health, Bethesda, Maryland, USA

    Juan M. Saavedra

  2. The DuPont Merck Pharmaceutical Company, Wilmington, Delaware, USA

    Pieter B. M. W. M. Timmermans

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© 1994 Springer Science+Business Media New York

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Inagami, T., Mizukoshi, M., Guo, DF. (1994). Angiotensin II Receptor. In: Saavedra, J.M., Timmermans, P.B.M.W.M. (eds) Angiotensin Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2464-9_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2464-9_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6049-0

  • Online ISBN: 978-1-4615-2464-9

  • eBook Packages: Springer Book Archive

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