Stabilization of Exametazime for Leucocyte Labelling: A New Approach using Tin Enhancement
We have examined the effect of the addition of two different stannous chloride formulations on the levels of primary lipophilic 99mTc exametazime. In the first study a solution containing 20 μg Sncl2 2H2 O was prepared (“in house”method) and used over a two week period. The mean level of radiochemical purity was 41% (range 11%-60%, n=6). In the second study a kit formulation containing 6.6 μg of Sncl2 2H2O/ml was prepared freshly each day. The mean radiochemical purity of 99mTc exametazime was 87% (range 68%-93%, n=5).
KeywordsRadiochemical Purity Labelling Efficiency Stannous Chloride Gentisic Acid Primary Complex
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