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Radiolabeled Blood Elements pp 273–277Cite as

Clinical Experiences with 111In Labeled Human Polyclonal IgG

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Part of the book series: NATO ASI Series ((NSSA,volume 262))

Abstract

All currently available scintigraphic techniques to localize infection have serious limitations. 99mTechnetium(Tc) methylenediphosphonate lacks specificity. Physiological excretion of 67 gallium(Ga) in the gut hampers image interpretation of suspected abdominal infection. 67 Ga also accumulates in areas of bone remodelling and the physical characteristics of the radionuclide are not particularly good. Preparation of 111indium labelled autologous leucocytes (111In-WBC) is time consuming, complicated, costly and - in this HIV era - potentially dangerous for patients and staff. Moreover, in patients with decreased peripheral leucocyte counts the latter technique is practically impossible.

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References

  1. Fischman AJ, Rubin RH, Khaw BA, Callahan RJ, Wilkinson R, Keech F, Nedelman M, Dragotakes S, Kramer PB, LaMuraglia GM, Lind S, Strauss HW. Detection of acute inflammation with 111-Indium labeled non-specific polyclonal IgG. Semin Nucl Med; 18: 335–344 (1988).

    Article  PubMed  CAS  Google Scholar 

  2. Rubin RH, Fischman AJ, Callahan RJ, Khaw BA, Keech F, Ahmad M, Wilkinson R, Strauss HW. In-111 labeled nonspecific immunoglobulin scanning in the detection of focal infection. N Eng J Med; 321: 935–940 (1989).

    Article  CAS  Google Scholar 

  3. Oyen WJG, Claessens RAMJ, van Horn JR, van der Meer JWM, Corstens FHM. Scintigraphic detection of bone and joint infections with indium-111 labeled nonspecific polyclonal human immunoglobulin G. J Nucl Med; 31: 403–412 (1990).

    PubMed  CAS  Google Scholar 

  4. Oyen WJG, Van Horn JR, Claessens RAMJ, Slooff TJJH, Van der Meer JWM, Corstens FHM. Diagnosis of bone, joint and prothesis infections with indium-111 labeled nonspecific human immunoglobulin G scintigraphy. Radiology; 182: 195–199 (1992).

    PubMed  CAS  Google Scholar 

  5. Oyen WJG, Van Horn JR, Claessens RAMJ, Slooff TJJH, Van der Meer JWM, Corstens FHM. Diagnosing prosthetic joint infections. J Nucl Med; 32:2195–2196 (1991).

    PubMed  CAS  Google Scholar 

  6. Oyen WJG, Netten PM, Lemmens JAM, Claessens RAMJ, Lutterman JA, Van der Vliet JA, Goris RJA, Van der Meer JWM, Corstens FHM. Evaluation of infectious diabetic foot complications with indium-111 labeled human nonspecific immunoglobulin G. J Nucl Med; 33:1330–1336 (1992)

    PubMed  CAS  Google Scholar 

  7. Oyen WJG, Claessens RAMJ, Raemaekers JMM, De Pauw BE, Van der Meer JWM, Corstens FHM. Diagnosing infection in febrile granulocytopenic patients with indium-111 labeled human IgG. J Clin Oncol; 10:61–68 (1992).

    PubMed  CAS  Google Scholar 

  8. Oyen WJG, Claessens RAMJ, Van der Meer JWM, Rubin RH, Strauss HW, Corstens FHM. Indium-111 labeled human nonspecific immunoglobulin G: a new radiopharmaceutical for imaging infectious and inflammatory foci. Clin Inf Dis; 14:1110–1119 (1992).

    Article  CAS  Google Scholar 

  9. Oyen WJG, Claessens RAMJ, van der Meer JWM, Corstens FHM. Detection of subacute infectious foci with indium-111 labeled autologous leukocytes and with indium-111 labeled human nonspecific immunoglobulin G: a prospective comparative study. J Nucl Med; 32:1854–1860 (1991).

    PubMed  CAS  Google Scholar 

  10. Hnatowich DJ, Childs RL, Lanteigne D, Najafi A. The preparation of DTPA-coupled antibodies radiolabeled with metallic radionuclides: an improved method. J Immunol Meth; 65:147–157 (1983).

    Article  CAS  Google Scholar 

  11. Oyen WJG, Naber AHJ, Claessens RAMJ, van der Meer JWM, Corstens FHM. Evaluation of inflammatory bowel disease activity with indium-111 labeled human nonspecific immunoglobulin G. J Nucl med; 33:919 (1992).

    Google Scholar 

  12. Petersdorf RG and Beeson PB. Fever of unexplained origin: report of 100 cases. Medicine; 40:1–30 (1961).

    Article  PubMed  CAS  Google Scholar 

  13. De Kleijn EMHA, Oyen WJG, Claessens RAMJ, Corstens FHM, Van der Meer JWM. Scintigraphy with indium-111 labeled polyclonal human immunoglobulin G (in-111-IgG) in patients with fever of unknown origin (FUO). Nucl Med Commun; 13:626 (1992).

    Google Scholar 

  14. Lange JMA, Boucher CAB, Hollak CEM, Wiltink EHH, Reiss P, Van Royen EA, Roos M, Danner SA, Goudsmit J. Failure of zidovudine prophylaxis after accidental exposure to HIV-1. N Eng J Med; 322:1375–1377 (1990).

    Article  CAS  Google Scholar 

  15. Rojas-Burko J. Health officials reactions to infection mishaps. J Nucl Med; 33:13N–27N (1992).

    Google Scholar 

  16. Oyen WJG, Claessens RAMJ, van der Meer JWM, Corstens FHM. Biodistribution and kinetics of radiolabeled proteins in rats with focal infection. J Nucl Med; 33:338–394 (1992).

    Google Scholar 

  17. Claessens RAMJ, Oyen WJG, Koenders EB, Tibben JG, Massuger LFAG, Corstens FHM. Potentials and pitfalls of indium labeled and iodinated proteins for scintigraphy of infectious disease and malignancy. Eur J Nucl Med; 19:700 (1992).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

    F. H. M. Corstens, W. J. G. Oyen & R. A. M. J. Claessens

  2. Department of General Internal Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

    J. W. M. van der Meer

Authors
  1. F. H. M. Corstens
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  2. W. J. G. Oyen
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  3. J. W. M. van der Meer
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  4. R. A. M. J. Claessens
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, CSUB Hospital “Princeps d’Espanya”, Barcelona, Spain

    J. Martin-Comin

  2. Division of Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    M. L. Thakur

  3. Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain

    C. Piera

  4. Department of Nuclear Medicine, CSUB Hospital “Princeps d’Espanya”, Barcelona, Spain

    M. Roca

  5. Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain

    F. Lomeña

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© 1994 Springer Science+Business Media New York

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Corstens, F.H.M., Oyen, W.J.G., van der Meer, J.W.M., Claessens, R.A.M.J. (1994). Clinical Experiences with 111In Labeled Human Polyclonal IgG. In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_41

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  • DOI: https://doi.org/10.1007/978-1-4615-2462-5_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6048-3

  • Online ISBN: 978-1-4615-2462-5

  • eBook Packages: Springer Book Archive

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