Abstract
After an initial enthusiasm, ten to fifteen years ago, in the development of new techniques for imaging in vivo lymphocyte traffic and pathological lymphocytic infiltrations in tissues, research in this field is now facing a slow progress.
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R.J.M. Ten Berge, A.T. Natarajan, M.R. Hardeman, E.A. Van Royen, and P. Schellekens. Labelling with Indium-111 has detrimental effects on human lymphocytes: concise communication. J. Nucl. Med.; 24:615 (1983).
B. Fisher, B.S. Packard, E.J. Reed, J.A. Carrasquillo, C.S. Carter, S.L. Topalian, J.C. Yang, P. Yolles, S.A. Larson and S.A. Rosenberg. Tumor localization of adoptively transferred Indium-111 labelled tumor infiltrating lymphocytes in patients with metastatic melanoma. J. Clin. Oncol.; 7:250 (1989).
J.P. Lavender, J.M. Goldman, R.N. Arnot and M.L. Thakur. Kinetics of Indium-111 labelled lymphocytes in normal subjects and patients with Hodgkin’s disease. Br. Med. J; 2:797 (1977).
K.G. Shmidt, B.S. Poulsen, J.W. Rasmussen, J. Johansen and M. Ronne. Tc-99m-HMPAO as a lymphocyte label. In: Radiolabelled cellular blood elements. Ed. H. Sinzinger and M. L. Thakur. Wiley-Liss Inc. New York. 209 (1990).
M. De Schrijver, K. Streule, R. Senekowistch and R. Fridrich. Scintigraphy of inflammation with nanometer-sized colloidal tracers. Nucl. Med. Comm.; 8:895 (1987).
D. Block, M.V. Ogtrop, J.W. Arndt, J.A.J. Camps, R.I.J. Feitsma, M. Goedemans and E.K.J. Pauwels. Detection of inflammatory lesions with radiolabelled immunoglobulins. Eur. J. Nucl. Med.; 16:303 (1990).
A.J. Fishman, R.A. Rubin, J.A. White, E. Locke, R.A. Wilkinson, M. Nedelman, R.J. Callahan, B. An Khan and H.W. Strauss. Localization of Fc and Fab fragments of nonspecific polyclonal IgG at focal sites of inflammation. J. Nucl. Med.; 31:1199 (1990).
R.M. Macklis, W.D. Kaplan, J.L. Ferrara, B.M. Kinsey, A.I. Kassis and S.J. Burakoff. Biodistrubution studies of anti-Thy 1.2 IgM immunoconjugates: implications for radioimmunotherapy. Int. J. Radiat Oncol Biol Phys; 15:383 (1988).
P. Thedrez, J. Paineau, Y. Jacques, J.F. Chatal, A. Pelegrin, C. Bouchard and J.P. Soulillou. Biodistribution of an anti-interleukin 2 receptor monoclonal antibody in rat recipients of a heart allograft, and its use as a rejection marker in gamma scintigraphy. Transplantation; 48:367 (1989).
I. Loutfi, P.M. Chisholm, D. Bevan and J.P. Lavender. In vivo imaging of rat lymphocytes with an indium 111-labelled anti-T cell monoclonal antibody: a comparison with indium 111-labelled lymphocytes. Eur. J. Nucl. Med.; 16:69 (1990).
P. Pozzilli, C. Pozzilli, P. Pantano, M. Negri, D. Andreani and A.G. Cudworth. Tracking of indium-111 oxine labelled lymphocytes in autoimmune tryroid disease. Clin. Endocrinol; 19:111 (1983).
W.S. Selby, G. Janossy, M. Bosil and D.P. Jewell. Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques. Gut; 25:32 (1984).
T.A. Waldmann, C.K. Goldman, R.J. Robb, J.M. Depper, W.J. Leonard, S.O. Sharrow, K.F. Bongiovanni, S.J. Korsmeyer and W.C. Greene. Expression of interleukin 2 receptors on activated human B cells. J. Exp. Med.; 160:1450 (1984).
A. Signore, P.C.L. Beverley, A. Parman, M. Negri and P. Pozzilli. Labelling of interleukin-2 (IL2) with 123-iodine with retention of its capacity to bind to activated lymphocytes. Exp. Clin. Endocrinol; 89:301 (1987).
A. Signore, A. Parman, P. Pozzilli, D. Andreani and P.C.L. Beverley. Detection of activated lymphocytes in endocrine pancreas of BB/W rats by injection of 123-interleukin-2: an early sign of type 1 diabetes. Lancet; 2:537 (1987).
A. Signore, M. Chianelli, A. Toscano, G. Ronga, L. Monetini, C.C. Nimmon, K.E. Britton, P. Pozzilli and M. Negri. A radiopharmaceutical for imaging areas of lymphocytic infiltration: 123I-Interleukin-2. Labelling procedure and animal studies. Nucl. Med. Commun.; 13:713 (1992).
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Signore, A. (1994). In Vivo Detection of Lymphocytic Infiltration: Present Status and New Prospects. In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_40
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DOI: https://doi.org/10.1007/978-1-4615-2462-5_40
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