Abstract
The localisation of infectious diseases has become a challenge for the physicians specialised in nuclear medicine7. Years ago we used Ga-67 for the diagnosis of inflammatory diseases and achieved good results. A major disadvantage of this isotope consists in the fact that colon excretion may be found therefore the interpretation of higher bowel uptake is often problematic. Moreover, the radiation dose is very high4. Since Thakur and other groups have reported the possibility of labeling leucocytes with 111Indium-oxine this method has won a dominating place in imaging inflammatory processes10. The introduction of anti-granulocyte antibodies has offered a new possibility of coping with this diagnostic problem1,5,9. We have used 99mTc labeled antibodies.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hotze AL, Briele B, Overbeck B, Kropp J, Gruenwald F, Mekkawy MA, von Smekal A, Moeller F, Biersack HJ. Technetium-99m-labeled anti-granulocyte antibodies in suspected bone infections. J Nucl Med, 33:526–531 (1992).
Kroiss A, Böck F, Perneczky G, Auinger Ch, Weidlich G, Kleinpeter G, Brenner H.Immunszintigraphie zur Aufdeckung von Entzündungsherden bei Knochen-und Gelenkserkrankungen. Wien Klin Wochenschr, 102:713–717 (1990).
Kroiss A, Kölbl Ch, Tuchmann A, Auinger Ch, Weidlich G, Weiss W, Neumayr A.Immunszintigraphie (IS) bei entzündlichen Erkrankungen mit Tc-99m-MAK BW 250/183. Acta Med Austriaca, 16:11–16 (1989).
Kroiss A, Weiss W, Kahn P, Neumayr A. Untersuchungen von Oberbaucherkrankungen mittels Gallium-67-Zitrat. In:“Nuklearmedizin”, Schmidt HAE, Woldring M Hrsg, Schattauer, Stuttgart New York (1977).
Lind P, Langsteger W, Költringer P, Dimai HP, Passl R, Eber O. Immunoscintigraphy of inflammatory processes with a technetium-99m-labeled monoclonal antigranulocyte-antibody (Mab BW 250/183). J Nucl Med, 31:417–423 (1990).
Oyen WJG, Netten PM, Lemmens AM, Claessens RMJ, Lutterman JA, van der Vliet JA, Goris RJA, van der Meer JWM, Corstens FHM. Evaluation of infectious diabetic foot complications with Indium-111-labeled human nonspecific immunoglobulin G. J Nucl Med, 33: 1330–1336 (1992).
Peters AM. Editorial: Imaging inflammation: courrent role of labeld autologous leukocytes. J Nucl Med, 33: 65–67 (1992).
Schwarz A, Steinsträßer A. A novel approach to 99m-Tc-labeled monoclonal antibody. J Nucl Med, 28: 721 (Abstract) (1987).
Seybold K, Locher JT, Coosemans C, Andreas RY, Schubiger AP, Bläuenstein P. Immunoscintigraphic localization of inflammatory lesions: clinical experience. Eur J Nucl Med, 13: 587–593 (1988).
Thakur ML, Lavender JP, Arnot RN, Silvester DJ, Segal AW. Indium-111-labeld autologous leukocytes in man. J Nucl Med, 18: 1014–1021 (1977).
Weidlich G, Kroiss A, Auinger CH, Schernthaner G. Immunoscintigraphy for detection of foot infections in diabetic patients. Diabetologia, 33: A24 (Abstract) (1990).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Kroiss, A., Auinger, C., Weidlich, G., Böck, F., Perneczky, G., Neumayr, A. (1994). Diagnosis of Inflammatory Bone and Joint Diseases with Monoclonal Antibodies (BW 250/183). In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_36
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2462-5_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6048-3
Online ISBN: 978-1-4615-2462-5
eBook Packages: Springer Book Archive