Skip to main content
SpringerLink
Log in

Peptides in Biomedical Sciences: Principles and Practice

  • Chapter
Book cover Radiolabeled Blood Elements

Part of the book series: NATO ASI Series ((NSSA,volume 262))

Abstract

This review will discuss the evolution of radiopharmaceutical carriers and how peptides provide a new opportunity to develop highly specific carriers with desirable properties. The technical challenges in developing 99mtechnetium labeled peptides for imaging will also be discussed as well as the role this technology promises to play in the growth in imaging. Finally a specific example of the application of this technology to imaging unstable atherosclerotic plaque will be presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hoffman T. Anticipating, Recognizing, and Preventing Hazards Associated with In Vivo Use of Monoclonal Antibodies: Special Considerations Related to Human Anti-Mouse Antibodies. Cancer Research (Suppl.), 50, 1049s–1050s (1990)

    CAS  Google Scholar 

  2. Johnson L. L., Seldin D. W., Becker L. C., et al. Antimyosin Imaging in Acute Transmural Myocardial Infarctions: Results of a Multicenter Clinical Trial. J. Am. Coll. Cardiol., 13, 27–35 (1989).

    Article  PubMed  CAS  Google Scholar 

  3. Lees R. S., Lees A. M., Strauss H. W. External Imaging of Human Atherosclerosis. J. Nucl. Med., 24, 154–156 (1983)

    PubMed  CAS  Google Scholar 

  4. Lees A. M., Lees R. S., Schoen F. J., Isaacsohn J. L., Fischman A. J., McKusick K. A., Strauss H. W. Imaging Human Atherosclerosis with 99mTc-labeled Low Density Lipoproteins. Arteriosclerosis, 8, 461–470 (1988)

    Article  PubMed  CAS  Google Scholar 

  5. Shih I.-L., Lees R. S., Chang M. Y., Lees A. M. Focal Accumulation of an Apolipoprotein B-based Synthetic Oligopeptide in Healing Rabbit Arterial Wall. Proc. Natl. Acad. Sci., USA 87, 1436–1440 (1990)

    Article  PubMed  CAS  Google Scholar 

  6. Vallabhajosula S., Chinol M., Goldsmith S. J., Lister-James J., Dean R. T. Iodine-123 Labeled SP4 (Synthetic Oligopeptide): A New Radiopharmaceutical to Image Atherosclerotic Lesions In Vivo. J. Nucl. Med. (Abstract), 32, 1842 (1991)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Diatech, Inc., Londonderry, New Hampshire, USA

    R. T. Dean & J. L. -James

  2. Health Sciences and Technology, Harvard University and M.I.T., USA

    R. S. Lees (Professor, President)

  3. Boston Heart Foundation, USA

    R. S. Lees (Professor, President) & A. M. Lees (Assistant Professor of Medicine, Associate Director)

  4. Harvard Medical School and Deaconess Hospital, USA

    A. M. Lees (Assistant Professor of Medicine, Associate Director)

  5. Mt. Sinai Medical Center, New York, NY, USA

    S. Vallabhajosula & S. J. Goldsmith

Authors
  1. R. T. Dean
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. L. -James
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. S. Lees
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. M. Lees
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Vallabhajosula
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. J. Goldsmith
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, CSUB Hospital “Princeps d’Espanya”, Barcelona, Spain

    J. Martin-Comin

  2. Division of Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    M. L. Thakur

  3. Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain

    C. Piera

  4. Department of Nuclear Medicine, CSUB Hospital “Princeps d’Espanya”, Barcelona, Spain

    M. Roca

  5. Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain

    F. Lomeña

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Dean, R.T., -James, J.L., Lees, R.S., Lees, A.M., Vallabhajosula, S., Goldsmith, S.J. (1994). Peptides in Biomedical Sciences: Principles and Practice. In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2462-5_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6048-3

  • Online ISBN: 978-1-4615-2462-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation