Abstract
Atherosclerosis is a main cause of morbidity and mortality. Standard imaging techniques such as CT scanning, magnetic resonance imaging, ECO-DOPPLER, and angiography are inneffective to detect atheromatous plaques in early stages of developement, when the lesions are most metabolically active and medical interventions could be beneficial. There is therefore a clinical need to develop a noninvasive method that could assess the presence and the extension of atherosclerotic disease in patients in monitoring treatment.
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References
J. Rosen, P. Butler, G. Meinken, T. Wang, R. Ramakrishnan, S. Srivastava, P. Alderson, H. Ginsberg. Indium-111 labeled LDL: A potencial agent for imaging Atherosclerotic disease and lipoprotein biodistribution.J.Nucl. Med. 31: 343–350 (1990)
A. Fischman, R. Rubin, B. Khaw, P. Kramer, R. Wilkinson, M. Ahmad, M. Needelman, E. Locke, N. Nosull, W. Staruss. Radionuclide imaging f experimental atherosclerosis with nonspecific polyclonal immunoglobulin G. J.Nucl.Med., 30: 1095–1100 (1989).
I. Virgolini, P. Angelberger, J. O’Grady, H. Sinzinger. Low density lipoprotein labelling characterizes experimentally induced atherosclerotic lesions in rabbits in vivo as to presence of foam cells and endothelial coverage. Eur.J.Nucl Med., 18: 944–947 (1991).
I. Virgolini, F. Rauscha, G. Lupatelli, A. Ventura, J. O’Grady, H. Sinzinger. Autologous low-density-lipoprotein labelling allows characterization of human atherosclerotic lesions in vivo as to presence of foam cells and endothelial coverage. Eur.J.Nucl Med, 18: 948–951 (1991).
F. Corstens, R. Claessens. Imaging inflammation with human polyclonal immunoglobulin: not looked for but discoverd. Eur.J.Nucl Med, 19: 155–158 (1992).
C.H. Paik K. Yokoyama, J.C. Reynolds, S.M. Quadri, C.Y. Min, S.Y. Shin, P.J. Maloney, S.M. Larson, R.C. Reba. Reduction of background activities by introduction of a Diester linkage between antibody and a chelate in radioimmunodetection of tumor. J.Nucl. Med, 30: 1693–1701 (1989).
D.J. Hnatowich, R.L. Childs, D. Lanteigne, A. Najafi. The preparation of DTPA-coupled antibodies radiolabeled with metallic radionuclides: an improved method. J. of Immunol. Methods., 65: 147–157 (1983).
C.H. Paik, M.A. Ebbert, P.R. Murphy, C.R. Lassman, et col.Factors influencing DTPA conjugation with antibodies by ciclic DTPA anhidre. J.Nucl.Med., 24: 1158–1163 (1983).
C.H. Paik, J.J. Hong, M.A. Ebbert, S.C. Heald, R.C. Reba. W.C. Eckelman. Relative reactivity od DTPA immunoreactive antibody-DTPA conjugates, and nonimmunoreactive antibody-DTPA conjugates toward Indium-111. J.Nucl.Med, 26: 482–487 (1985).
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Prat, L. et al. (1994). 111in-Polyclonal IgG and 125I-LDL Accumulation in Experimental Arterial Wall Injury. In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_25
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DOI: https://doi.org/10.1007/978-1-4615-2462-5_25
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