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Influence of Platelet Membrane Sialic Acid and Platelet Associated IgG on Ageing and Sequestration of Blood Platelets in Baboons

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Radiolabeled Blood Elements

Part of the book series: NATO ASI Series ((NSSA,volume 262))

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Abstract

Blood platelets circulate for approximately 10 days in normal humans. The macrophages of the monocyte-macrophage system then recognise them as old and phagocytose and destroy them. The mechanism through which the macrophages recognise the “old” platelets is not known. A hypothesis to explain red cell ageing and sequestration implicates that membrane sialic acid may play a role. According to this view, red cells loose sialic acid while they are circulating. This exposes a senescent cell antigen on the red cell membrane. IgG recognises and binds to the antigen. Once sufficient antibody-antigen complex is formed, the macrophages recognise the red cells as “foreign” and phagocytose and destroy them1.

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References

  1. Kay MMB. Isolation of a phagocytosis-inducing IgG-binding site in senescent somatic cells. Nature, 289: 491–494 (1981).

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  2. Greenberg JP, Packham MA, Cazenaeve JP, Reimers HJ, Mustard JF. Effect on platelet function of removal of sialic acid by neuraminidase. Laboratory Investigation, 32: 476–484 (1975).

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  3. Kotzé HF, Lötter MG, Badenhorst PN, Heyns A du P. Kinetics of In-111-platelets in the baboon. I. Isolation and labelling of a viable and representative platelet population. Thrombosis and Haemostasis, 53: 404–407 (1985).

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  4. Kotzé HF, Lötter MG, Badenhorst PN, Heyns A du P. Kinetics of In-111-platelets in the baboon. II. In vivo distribution and sites of sequestration. Thrombosis and Haemostasis, 53: 408–410 (1985).

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Author information

Authors and Affiliations

  1. Department of Haematology, University of the Orange Free State, Bloemfontein, South Africa

    H. F. Kotzé, V. van Wyk, J. P. Roodt, M. G. Lötter & P. N. Badenhorst

  2. South African Blood Transfusion Services, Johannesburg, South Africa

    A. du P Heyns

Authors
  1. H. F. Kotzé
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  2. V. van Wyk
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  3. A. du P Heyns
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  4. J. P. Roodt
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  5. M. G. Lötter
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  6. P. N. Badenhorst
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Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, CSUB Hospital “Princeps d’Espanya”, Barcelona, Spain

    J. Martin-Comin

  2. Division of Nuclear Medicine, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    M. L. Thakur

  3. Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain

    C. Piera

  4. Department of Nuclear Medicine, CSUB Hospital “Princeps d’Espanya”, Barcelona, Spain

    M. Roca

  5. Department of Nuclear Medicine, Hospital Clinic, Barcelona, Spain

    F. Lomeña

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© 1994 Springer Science+Business Media New York

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Kotzé, H.F., van Wyk, V., Heyns, A.d.P., Roodt, J.P., Lötter, M.G., Badenhorst, P.N. (1994). Influence of Platelet Membrane Sialic Acid and Platelet Associated IgG on Ageing and Sequestration of Blood Platelets in Baboons. In: Martin-Comin, J., Thakur, M.L., Piera, C., Roca, M., Lomeña, F. (eds) Radiolabeled Blood Elements. NATO ASI Series, vol 262. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2462-5_19

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  • DOI: https://doi.org/10.1007/978-1-4615-2462-5_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6048-3

  • Online ISBN: 978-1-4615-2462-5

  • eBook Packages: Springer Book Archive

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