Abstract
The L1 major capsid protein of human papillomavirus type 16 (HPV-16) is potentially a useful reagent for studying immune responses to this virus and for the development of a vaccine to control the occurrence of primary infections and HPV-16-associated genital. carcinomas1,2. However immunological. studies utilizing L1 protein have been impeded by the lack of availability of a correctly folded form of the protein. Gene expression technology offers an efficient means for producing large amounts of the protein provided the problems that affect recombinant proteins can be overcome. Since these problems can require the testing of different expression systems, it would be an advantage for the L1 coding sequence to be readily insertable into a variety of expression plasmids and carry sequence characteristics favoring efficient expression in different cellular and genetic environments.
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© 1994 Springer Science+Business Media New York
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Kelsall, S.R., Kulski, J.K. (1994). A Gene Cassette for High Level Expression of the Li Capsid Protein of HPV-16 in Heterologous Cells. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_9
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DOI: https://doi.org/10.1007/978-1-4615-2449-6_9
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