Abstract
Human papillomavirus (HPV) DNA, predominantly of the HPV16 genotype, can he detected in more than 90% of the human cervical. carcinomas1. The “high risk” HPV types, including HPV16, are believed to play an important role in the pathogenesis of human cervical. cancer. The ability of HPV16 to in vitro immortalize human keratinocytes2and the dependence on HPV 16 expression for preservation of the transformed phenotype of cervical. cancer-derived cell lines3 suggests direct involvement of HPV 16 in the multi-step process of cervical. carcinogenesis. Cervical. cancer and other HPV-related cancers are more commonly seen in immunosuppressed individuals4,5. This suggests that proper immunosurveillance interferes with HPV-associated tumor development and that T cell immunity, in particular mediated by cytotoxic T lymphocytes (CTL), is important in the defense against virus induced tumors.
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Feltkamp, M.C.W., Vierboom, M.P.M., ter Schegget, J., Melief, C.J.M., Kast, W.M. (1994). Fine Characterization of the HPVI6 E7 49-57 Tumor Protective Cytotoxic T Cell Epitope “Rahynivtf”. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_43
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DOI: https://doi.org/10.1007/978-1-4615-2449-6_43
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