Abstract
Human papillomaviruses (HPVs) are strictly epithelial. pathogens and there is increasing evidence that infection by high risk HPV types has to be regarded as a major risk factor in the development of certain cancers such as the carcinoma of the cervix. Increased incidence of HPV induced lesions and cancer is a complication in immunosuppressed individuals, particularly in those patients with disturbed cell mediated immunity1,2. Conversely, prophylactic and therapeutic vaccination may represent a promising strategy to deal. with the HPV associated health threat3. If successful, vaccines would have a profound effect on HPV associated morbidity and mortality with major benefits in both developed and in underdeveloped countries. However, our understanding of the role of the immune system in controlling HPV infection is still fragmentary.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
R. Hoover and J.F. Fraumeni, Risk of cancer in renal. transplant patients, Lancet ii. 55 (1973).
M. Laga, J.P. Icenogle, R. Marsella, A.T. Manoka, N. Nzila, R.W. Ryder, S.H. Vermund, W.L. Heyward, A. Nelson and W.C. Reeves, Genital. papillomavirus infection and cervical. dysplasia — Opportunistic complication of HPV infection, Int J Cancer 50:45 (1992).
M.S. Campo, Vaccination against papillomavirus, Cancer Cells 3:421 (1991).
M. Okabayashi, M.G. Angell, N.D. Christensen and J.W. Kreider, Morphometric analysis and identification of infiltrating leucocytes in regressing and progressing Shope rabbit papillomas, Int I Cancer 49:919 (1991).
H. Tagami, A. Ogino, M. Takigawa, S. Imamura and S. Ofugi, Regression of plane warts following spontaneous inflammation: a histopathological. study, Br J Dermatol 90:147 (1974).
H.A. Cubie, M. Norval, L. Crawford, L. Banks and T. Crook, Lymphoproliferative response to fusion proteins of human papillomaviruses in patients with cervical. intraepithelial. neoplasia, Epidemiol Infect. 103:625 (1990).
F.C. Charleson, M. Norval, E.C. Benton and J.A. Hunter, Lymphoproliferative response to human papillomaviruses in patients with cutaneous warts, Br J Dermatol. 127:551 (1992).
J. Viac, J. Thivolet and Y. Chardonnet. Specific immunity in patients suffering from recurring warts before and after repetitive intradermal. tests with human papillomavirus, Br J Dermatol. 97:365 (1977).
R. Höpfl, M. Sandbichler, N. Sepp, K. Heim, E. Miiller-Holzner, B. Wartusch, O. Dapunt, I. Jochmus-Kudielka, J. Ter Meulen, L. Gissmann and P. Fritsch, Skin test for HPV type 16 proteins in cervical. intraepithelial. neoplasia, Lancet 337:373 (1991).
C. S. McLean, J. S. Sterling, J. Mowat, A.A. Nash and M. A. Stanley, Delayed-type hypersensitivity response to human papillomavirus type 16 E7 protein in a mouse model, J General. Virol. 74:239 (1993).
J.W. Kreider and G.L. Barlett: The Shope papilloma-carcinoma complex of rabbits: A model system of neoplastic progression and spontaneous regression, Adv Cancer Res. 35:81 (1981).
R. M. Höpfl, N. D. Christensen, M.G. Angell and J. W. Kreider, Skin test to assess immunity against Cottontail Rabbit Papillomavirus Antigens in Rabbits with Progressing Papillomas or after Regression, J Invest Dermatol. 101:127 (1993).
M.G. Angell, N.D. Christensen and J.W. Kreider, An in vitro system for studying the initial. stages of cottontail rabbit papillomavirus (CRPV) infection, J Virol Methods 39:207 (1992).
J. W. Kreider, M.K. Howett, A. E. Leure-Dupree, R.J. Zaino and J. A. Weber, Laboratory production in vivo of infectious human papillomavirus type 11, J Virol. 61:590 (1987).
J.W. Kreider. “Viruses in Naturally Occurring Cancers. Book A,” Cold Spring Harbor Press, Cold Spring Harbor (1980).
J.L. Brandsma and W. Xiao, Infectious Virus Replication in Papillomas Induced by Molecular Cloned Cottontail Rabbit Papillomavirus DNA, J Virol. 67: 567 (1993).
C.A. Evans, L.R. Gorman, Y.Ito and R.S. Weiser, A vaccination procedure which increases the frequency of regressions of Shope papillomas of rabbits, Nature 193:288 (1962).
M.F. Naylor, K.H. Neldner, G.K. Yarbrough, T.J. Rosio, M. Iriondo and J. Yeary, Contact immunotherapy of resistant warts, J Am Acad Dermatol 19:679 (1988).
S. Aiba, M. Rokego and H. Tagami, Immunohistological. analysis of the phenomenon of spontaneous regression of numerous flat warts, Cancer 58.1246 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Höpfl, R.M., Christensen, N.D., Heim, K., Kreider, J.W. (1994). Skin Test Reactivity to Papilloma Cells is Long Lasting in Domestic Rabbits after Regression of Cottontail Rabbit Papillomavirus Induced Papillomas. In: Stanley, M.A. (eds) Immunology of Human Papillomaviruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2449-6_41
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2449-6_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6041-4
Online ISBN: 978-1-4615-2449-6
eBook Packages: Springer Book Archive